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首页> 外文期刊>Journal of cellular physiology. >A robust six-miRNA prognostic signature for head and neck squamous cell carcinoma
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A robust six-miRNA prognostic signature for head and neck squamous cell carcinoma

机译：一个健壮的six-miRNA预后负责人的签名和颈部鳞状细胞癌

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Head and neck squamous cell carcinoma (HNSCC) remains a major health problem worldwide. We aimed to identify a robust microRNA (miRNA)-based signature for predicting HNSCC prognosis. The miRNA expression profiles of HNSCC were obtained from The Cancer Genome Atlas (TCGA) database. The TCGA HNSCC cohort was randomly divided into the discovery and validation cohort. A miRNA-based prognostic signature was built up based on TGCA discovery cohort, and then further validated. The downstream targets of prognostic miRNAs were subjected to functional enrichment analyses. The role of miR-1229-3p, a prognosis-related miRNA, in tumorigenesis of HNSCC was further evaluated. A total of 305 significantly differentially expressed miRNAs were found between HNSCC samples and normal tissues. A six-miRNA prognostic signature was constructed, which exhibited a strong association with overall survival (OS) in the TCGA discovery cohort. In addition, these findings were successfully confirmed in TCGA validation cohort and our own independent cohort. The miRNA-based signature was demonstrated as an independent prognostic indicator for HNSCC. A risk signature-based nomogram model was constructed and showed good performance for predicting the OS for HNSCC. The functional analyses revealed that the downstream targets of these prognostic miRNAs were closely linked to cancer progression. Mechanistically, in vitro analysis revealed that miR-1229-3p played a tumor promoting role in HNSCC. In conclusion, our study has developed a robust miRNA-based signature for predicting the prognosis of HNSCC with high accuracy, which will contribute to improve the therapeutic outcome.
机译：头颈部鳞状细胞癌(HNSCC)世界仍然是一个主要的健康问题。旨在确定一个健壮的微rna (microRNA的)的对预测预后HNSCC签名。HNSCC的microrna的表达谱从癌症基因组图谱(TCGA)数据库。TCGA HNSCC队列被随机分为发现和验证队列。建立了基于TGCA预后签名发现队列,然后进一步验证。下游预后microrna的目标进行功能富集分析。mir - 1229 - 3 - p的作用,一个prognosis-related microrna的,在肿瘤发生的HNSCC进一步评估。总共有305显著不同microrna表达HNSCC样本之间被发现和正常组织。签名是构造,它表现出一个强大的协会与总生存期(OS), TCGA发现队列。结果成功TCGA确诊验证组和我们自己的独立的队列。miRNA-based签名被证明是一个HNSCC独立预后指标。基于签名的诺模图模型风险构造并显示出良好的性能预测HNSCC的操作系统。分析表明,下游的目标这些预后microrna是紧密相连癌症的发展。分析显示,mir - 1229 - 3 - p扮演了一个肿瘤在HNSCC促进的作用。开发了一个健壮的miRNA-based签名预测HNSCC高的预后将有助于提高准确性治疗的结果。

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