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首页> 外文期刊>Journal of cellular physiology. >Prognostic value of periostin in multiple solid cancers: A systematic review with meta-analysis
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Prognostic value of periostin in multiple solid cancers: A systematic review with meta-analysis

机译：在多个固体periostin的预后价值癌症:系统回顾和荟萃分析

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Previous studies have shown that the expression of periostin (POSTN) is significantly correlated with prognosis in multiple solid cancers. However, the function of POSTN in tumorigenesis and its relationship with clinical outcomes have not been systematically summarized and analyzed. Thus, a meta-analysis was performed to evaluate the prognostic pertinence of POSTN in solid cancer. We conducted a systematic search in the PubMed, EMBASE, Web of Science, and Cochrane library databases, and a total of 10 studies were used to assess the association of POSTN expression and patients' overall survival (OS) and disease-free survival (DFS). The hazard ratio (HR) or odds ratio (OR) and their corresponding 95% confidence intervals (95% CIs) were further calculated to estimate the association between POSTN and relevant clinical parameters of solid cancer patients. The pooled results indicated that POSTN overexpression was associated with poor OS (HR = 2.35, 95% Cl = 1.88-2.93, p < .00001) and DFS (HR = 2.70, 95% Cl = 2.00-3.65, p < .00001) in a cohort of 993 patients with cancer. Subsequent analyses showed that the positive expression ratio of POSTN was evidently higher in cancer tissues than in normal tissues (OR = 7.44, 95% Cl = 3.66-13.95, p < .00001). In addition, subgroup analysis showed that POSTN was related to microvascular invasion (OR = 5.09, 95% Cl = 3.07-8.44, p < .00001), tumor differentiation (OR = 2.03, 95% Cl = 1.41-2.91, p = .0001), and lymph node metastasis (OR = 3.05, 95% Cl = 2.01-4.64, p < .00001). These data showed that POSTN could be a credible prognostic biomarker and a potential therapeutic target in human solid cancer.
机译：以前的研究已经表明的表达periostin (POSTN)是显著相关的在多个固体癌症与预后。然而,POSTN在肿瘤发生的作用及其与临床结果之间的关系没有系统地总结和分析。因此,进行分析评估POSTN预后相关性的固体癌症。PubMed、EMBASE、网络科学,科克伦图书馆数据库,共10个研究用于评估POSTN协会表达与患者的总生存期(OS)和无病生存期(DFS)。(人力资源)或比值比(或)和相应的95%置信区间(95% CIs)计算估计之间的关系固体POSTN及相关临床参数癌症患者。, POSTN过度有关可怜的OS (HR = 2.35, 95% Cl = 1.88 - -2.93, p <.00001)和DFS (HR = 2.70, 95% Cl = 2.00 - -3.65, p< .00001) 993年一群患者癌症。阳性表达率POSTN是显然的在癌症组织中高于正常组织(或= 7.44,95% Cl = 3.66 - -13.95, p < .00001)。另外,亚组分析显示,POSTN微血管浸润相关(或= 5.09,95%Cl = 3.07 - -8.44, p < .00001),肿瘤分化(或= 2.03,95% Cl = 1.41 - -2.91, p=。),淋巴结转移(或= 3.05,95%氯-4.64 = 2.01,p < .00001)。表明POSTN可能是一个可靠的预后生物标志物和潜在的治疗目标人类固体癌症。

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