Decreasing New York esophageal squamous cell carcinoma 1 expression inhibits multiple myeloma growth and osteolytic lesions

Fei Li; Fengshu Zhao; Miao LiMeng PanFangfang ShiHui XuDanfeng ZhengLing WangJun Dou

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Decreasing New York esophageal squamous cell carcinoma 1 expression inhibits multiple myeloma growth and osteolytic lesions

机译：纽约食管鳞状细胞减少癌1表达抑制多发性骨髓瘤增长和溶骨的病变

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New York esophageal squamous cell carcinoma 1 (NY-ESO-1) is aberrantly expressed in multiple myeloma (MM) patients, however, its role remains largely unknown. The present study aimed to investigate the effect of NY-ESO-1 knockdown on MM impact and provide evidence for targeting treatment of MM. Human MM U266 cells were infected with lentivirus-based small hairpin RNA-targeting NY-ESO-1 (LV-shNY-ESO-1). Cellular proliferation, colony-forming, migration, and invasion assays were employed. The expressions of cell cycle and epithelial-mesenchymal transition (EMT)-related molecules, MM growth, and mouse osteolytic lesions were evaluated. The results showed that the LV-shNY-ESO-l-U266 cells had a lower expression of NY-ESO-1 and a higher expressions of p21 and E-cadherin, and a weaker abilities of colony formation, drug-resistant to adriamycin, migration, and invasion than those of the control cells. Importantly, the knockdown of NY-ESO-1 inhibited significantly the U266 cell-induced MM growth and osteolytic lesions along with increasing the expressions of E-cadherin, p21, and p53 in mice challenged with LV-shNY-ESO-1-U266 cells. Collectively, our findings demonstrate that knockdown of NY-ESO-1 suppressed the U266 cell-induced MM growth and osteolytic lesions by inhibition of the MMs cell cycle and EMT. The NY-ESO-1 knockdown may be considered for future clinical trials in MM.

机译：纽约食管鳞状细胞癌1(NY-ESO-1)异常表达在多个骨髓瘤(MM)患者,然而,它的作用仍然存在很大程度上是未知的。调查的影响NY-ESO-1击倒MM影响和目标提供依据人类MM U266细胞治疗MM。感染了慢病毒为基础的小发夹RNA-targeting NY-ESO-1 (LV-shNY-ESO-1)。增殖、克隆形成、迁移和入侵检测被雇佣。细胞周期和epithelial-mesenchymal过渡(EMT) -相关分子,MM增长,和鼠标溶骨的损伤进行评估。表明LV-shNY-ESO-l-U266细胞了NY-ESO-1和更高的低表达p21的表达和钙粘蛋白,一个较弱的集落形成能力,耐药阿霉素、迁移和入侵比控制细胞。U266 NY-ESO-1抑制明显cell-induced MM增长和溶骨的病变随着增加的表达式钙粘蛋白、p21和p53在老鼠的挑战LV-shNY-ESO-1-U266细胞。研究结果表明,NY-ESO-1击倒增长和抑制了U266 cell-induced毫米抑制溶骨的病变的MMs细胞周期和EMT。考虑未来临床试验在毫米。

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来源
《Journal of cellular physiology.》 |2020年第3期|2183-2194|共12页
作者
Fei Li; Fengshu Zhao; Miao LiMeng PanFangfang ShiHui XuDanfeng ZhengLing WangJun Dou;
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Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing;

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正文语种英语
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Lytic Metastatic Bone Lesion; Epithelial-Mesenchymal Transition; Multiple MyelomaTCEAL1 geneMolecular Targeted TherapyCell Cyclecyclin dependent kinase inhibitor 1U266B1 cell lineCTAG1 protein, humanRNA Interference;

机译：溶解性转移性骨病变;Epithelial-Mesenchymal过渡;多个MyelomaTCEAL1 geneMolecular TherapyCell目标1 u266b1 Cyclecyclin依赖激酶抑制剂细胞lineCTAG1蛋白质,humanRNA干扰;

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1. Expression of Vascular Endothelial Growth Factor C and Its Clinical Significance in Human Esophageal Squamous Cell Carcinoma [J] . Hongxin Zhang, Lan Zhang, Kuisheng Chen, 癌症生物学与医学（英文版） . 2007,第002期
2. Triptolide Inhibits Cell Growth and Induces GO- G1 Arrest by Regulating P21wap1/cip1 and P27 kipl in Human Multiple Myeloma RPMI-8226 Cells [J] . Yuan Liu, Ling-lan Zeng, Yan Chen, 中国癌症研究：英文版 . 2010,第002期
3. Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究 [J] . Acta Anaesthesiologica Scandinavica . 2009,第10期

机译：Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究
4. Ultrasensitive enzyme-free immunoassay for squamous cell carcinoma antigen using carbon supported Pd-Au as electrocatalytic labels Jian Gao, Bin Du, Xiaoyue Zhang, Aiping Guo, Yong Zhang, Dan Wu, Hongmin Ma, [J] . Qin Wei Analytica chimica acta . 2014,第Null期

机译：Ultrasensitive enzyme-free immunoassay for squamous cell carcinoma antigen using carbon supported Pd-Au as electrocatalytic labels Jian Gao, Bin Du, Xiaoyue Zhang, Aiping Guo, Yong Zhang, Dan Wu, Hongmin Ma,
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6. pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs. [O] . Williams, Timothy K, Costantino, Christina L, Bildzukewicz, Nikolai A, 2010

机译：pp32 (aNp32a) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNas.

Decreasing New York esophageal squamous cell carcinoma 1 expression inhibits multiple myeloma growth and osteolytic lesions

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