Role of type 2 innate lymphoid cell and its related cytokines in tumor immunity

Jie Wan; Wei Cai; Huixuan WangJianjun ChengZhaoliang SuShengjun WangHuaxi Xu

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Role of type 2 innate lymphoid cell and its related cytokines in tumor immunity

机译：2型先天淋巴细胞和它的作用相关的细胞因子在肿瘤免疫

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Type 2 innate lymphoid cells (ILC2s) have multiple functions that can respond to allergic diseases, parasite infection, metabolic homeostasis, tissue repair, and adipose metabolism homeostasis. In these diseases, ILC2s can be activated by various inflammatory cytokines released by damaged cells. Activated ILC2s produce different type 2 cytokines, including interleukin (IL)-4, IL-5, IL-9, and IL-13, which involved in the pathogenesis of many diseases. In recent years, the relationship between ILC2s and tumor diseases has attracted more and more attention. The role of ILC2s in tumor immunity depends on its surface molecules and cytokine context. This review aims to conclude tumorigenic and antitumorigenic roles of ILC2s, and the characters of ILC2s-related cytokines in tumor diseases to provide a comprehensive overview of the impact of ILC2s in tumor immunity.

机译：2型先天淋巴细胞(ILC2s)有多个函数,可以应对过敏性疾病,寄生虫感染,代谢体内平衡,组织修复、脂肪代谢体内平衡。这些疾病,ILC2s可以通过各种被激活炎性细胞因子释放的受损细胞。激活ILC2s产生不同的2型细胞因子,包括白介素(IL) 4, IL-5,IL-9 IL-13,参与许多疾病的发病机制。ILC2s和肿瘤疾病之间的关系吸引了越来越多的关注。在肿瘤免疫ILC2s取决于它的表面分子和细胞因子上下文。结论肿瘤发生的和抗癌的作用ILC2s, ILC2s-related的字符细胞因子在肿瘤疾病提供一个全面概述ILC2s的影响肿瘤免疫。

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《Journal of cellular physiology.》 |2020年第4期|3249-3257|共9页
作者
Jie Wan; Wei Cai; Huixuan WangJianjun ChengZhaoliang SuShengjun WangHuaxi Xu;
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Department of Immunology, Jiangsu University, Zhenjiang, China;

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正文语种英语
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关键词
Tumor Microenvironment; tumor immunity; CytokinesLymphoid CellsTumours;

机译：肿瘤微环境;肿瘤;

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Role of type 2 innate lymphoid cell and its related cytokines in tumor immunity

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