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首页> 外文期刊>Journal of cellular physiology. >BZW2 promotes the malignant progression of colorectal cancer via activating the ERK/MAPK pathway
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BZW2 promotes the malignant progression of colorectal cancer via activating the ERK/MAPK pathway

机译：BZW2促进的恶性发展通过激活ERK / MAPK结肠直肠癌通路

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摘要

Colorectal cancer (CRC) is one of the most prevalent malignant solid cancers worldwide involving the dysregulation of multiple signaling molecules. However, the role and corresponding mechanism of basic leucine zipper and W2 domains 2 (BZW2) in CRC development, to our knowledge, has not been reported. We found BZW2 was overexpressed in human CRC tissues compared with that in paired adjacent colorectal samples. BZW2 overexpression was closely associated with tumor T stage (p = .030), metastatic lymph nodes (p = .037), TNM stage (p = .018) and the worse prognosis of CRC patients (p = .009). Moreover, BZW2 was an independent disadvantage prognostic factor (p = .031). BZW2 also showed an increased expression in different invasive CRC cell lines. Its silencing and overexpression diminished and increased cell proliferation, invasion, and migration in Colo205 and HCT116 cells via specifically activating of extracellular-signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling. Moreover, ERK/MAPK inhibitor PD98059 reverse the enhancement of cell proliferation, invasion, and migration in BZW2 overexpressing HCT116 cells. BZW2 silencing also inhibited subcutaneous tumors growth and p-ERK expression in vivo. BZW2 promotes the malignant progression of CRC via activating ERK/MAPK signaling, which provided a promising gene target therapy for CRC.
机译：结直肠癌(CRC)是最之一全球普遍恶性实体肿瘤涉及到多个信号的失调分子。机制的基本亮氨酸拉链和W2域2 (BZW2)在CRC开发中,据我们所知,还没有被报道。在人类的CRC组织相比在配对邻结直肠样本。超表达与肿瘤密切相关T (p = .030)阶段,转移性淋巴结(p =.037), TNM阶段(p = .018)和更糟CRC患者的预后(p = .009)。BZW2预后是一个独立的缺点因素(p = .031)。在不同的入侵CRC细胞系表达。沉默和超表达减弱增加细胞增殖、入侵和通过迁移Colo205和HCT116细胞具体的激活extracellular-signal-regulated激酶(ERK) /增殖蛋白激酶(MAPK)信号。反向增强细胞增殖,入侵,迁移BZW2 overexpressingHCT116细胞。皮下肿瘤生长和p-ERK表达式体内。CRC通过激活ERK / MAPK信号传导的提供了一个有前途的基因治疗CRC目标。

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