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首页> 外文期刊>Journal of cellular physiology. >Haspin inhibition delays cell cycle progression through interphase in cancer cells
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Haspin inhibition delays cell cycle progression through interphase in cancer cells

机译：Haspin抑制延迟细胞周期进程通过肿瘤细胞的间期

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摘要

Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) is a serine/threonine kinase pertinent to normal mitosis progression and mitotic phosphorylation of histone H3 at threonine 3 in mammalian cells. Different classes of small molecule inhibitors of haspin have been developed and utilized to investigate its mitotic functions. We report herein that applying haspin inhibitor CHR-6494 or 5-ITu at the G1/S boundary could delay mitotic entry in synchronized HeLa and U2OS cells, respectively, following an extended G2 or the S phase. Moreover, late application of haspin inhibitors at S/G2 boundary is sufficient to delay mitotic onset in both cell lines, thereby, indicating a direct effect of haspin on G2/M transition. A prolonged interphase duration is also observed with knockdown of haspin expression in synchronized and asynchronous cells. These results suggest that haspin can regulate cell cycle progression at multiple stages at both interphase and mitosis.
机译：Haspin(单倍体胚特异性核蛋白质激酶)是一种丝氨酸/苏氨酸激酶相关正常有丝分裂进程和有丝分裂组蛋白H3磷酸化的苏氨酸3哺乳动物细胞。分子的抑制剂haspin发达并利用调查其有丝分裂功能。抑制剂所对应在G1 / S - 6494或5-ITu边界可能会推迟有丝分裂进入同步海拉分别和U2OS细胞之后G2或S期延长。应用haspin抑制剂在S / G2边界足够的延迟在细胞有丝分裂发生吗行,因此,表明一个直接的影响haspin G2 / M过渡。持续时间也观察击倒的在同步和haspin表达式异步的细胞。haspin可以调节细胞周期进程有丝分裂间期和多个阶段。

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