• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >Expression and function of dopamine in odontoblasts
【24h】

Expression and function of dopamine in odontoblasts

机译：表达式和函数的多巴胺

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dopamine (DA) is produced from tyrosine by tyrosine hydroxylase (TH). A recent study has reported that DA promotes the mineralization of murine preosteoblasts. However, the role of DA in odontoblasts has not been examined. Therefore, in this investigation, we researched the expression of TH and DA in odontoblasts and the effects of DA on the differentiation of preodontoblasts (KN-3 cells). Immunostaining showed that TH and DA were intensely expressed in odontoblasts and preodontoblasts of rat incisors and molars. KN-3 cells expressed D1-like and D2-like receptors for DA. Furthermore, DA promoted odontoblastic differentiation of KN-3 cells, whereas an antagonist of D1-like receptors and a PKA signaling blocker, inhibited such differentiation. However, antagonists of D2-like receptors promoted differentiation. These results suggested that DA in preodontoblasts and odontoblasts might promote odontoblastic differentiation through Dl-like receptors, but not D2-like receptors, and PKA signaling in an autocrine or paracrine manner and plays roles in dentinogenesis.
机译：多巴胺(DA)是由酪氨酸酪氨酸羟化酶(TH)。报道称,DA促进矿化的小鼠preosteoblasts。成还没有检查。这个调查中,我们研究了表达式成的TH和DA和的影响DA preodontoblasts的分化(KN-3细胞)。DA在成和强烈的表达preodontoblasts大鼠切牙和磨牙。表示D1-like和D2-like受体细胞哒。KN-3细胞的分化,而一个D1-like受体的拮抗剂和PKA信号拦截器,抑制分化。受体促进分化。建议在preodontoblasts DA,成可能促进odontoblastic通过Dl-like受体分化,但是不是D2-like受体,和PKA信号自分泌或旁分泌的方式和扮演的角色牙质生成。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号