Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma

Farzad Rahmani; Aghigh Ziaeemehr; Soodabeh ShahidsalesMasoumeh GharibMajid KhazaeiGordon A. FernsMikhail RyzhikovAmir AvanSeyed M. Hassanian

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Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma

机译：监管的角色PI3K / AKT / mTOR的microrna信号在肝细胞的发病机制癌

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Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the PI3K/AKT/mTOR signaling axis. The recognition of the crucial role of miRNAs in hepatocarcinogenesis represents a promising area to identify novel anticancer therapeutics for HCC. The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC.

机译：肝细胞癌(HCC)是其中一个常见的人类恶性肿瘤发病率高在全球范围内。磷酸肌醇3-kinase /蛋白激酶B /哺乳动物雷帕霉素靶(PI3K / AKT / mTOR)信号与临床病理的有关肝细胞癌的特点。小分子核糖核酸(microrna)有显著的影响调节细胞增殖,分化、凋亡和新陈代谢通过针对mTOR / PI3K / AKT信号轴。在hepatocarcinogenesis代表一个microrna前景看好的领域来确定新的抗癌肝癌的治疗。总结了主要的发现监管职责的microrna PI3K / AKT / mTOR通路在肝细胞癌的发病机制。

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来源
《Journal of cellular physiology.》 |2020年第5期|4146-4152|共7页
作者
Farzad Rahmani; Aghigh Ziaeemehr; Soodabeh ShahidsalesMasoumeh GharibMajid KhazaeiGordon A. FernsMikhail RyzhikovAmir AvanSeyed M. Hassanian;
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Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences;

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正文语种英语
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关键词
Signal Transduction; Hepatocarcinogenesis; pathogenesisRegulatoryMicroRNAsHepatocellular Cancer;

机译：信号转导;Hepatocarcinogenesis;病原体;

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1. The Possible Role of Signal Regulatory Protein α1 in Hepatocellular Carcinoma [J] . SHANYunfeng, KANGBin, LIBaoan, 中德临床肿瘤学杂志：英文版 . 2003,第003期
2. BRMS1 performs an anti-tumor effect on renal cell carcinoma via inhibition of PI3K/AKT/mTOR signaling pathway [J] . Ya-nan Cong, Zhen-guo Wang, Lin Zhao 海南医科大学学报(英文版) . 2019,第016期
3. BRMS1 performs an anti-tumor effect on renal cell carcinoma via inhibition of PI3K/AKT/mTOR signaling pathway [J] . Ya-nan Cong, Zhen-guo Wang, Lin Zhao 海南医科大学学报（英文版） . 2019,第016期
4. Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221 [J] . Salama Rania M., Abdel-Latif Ghada A., Abbas Samah S., Neuropharmacology . 2020,第期

机译：羊角酮诱导帕金森病的神经保护作用在大鼠中：PI3K / AKT / MTOR信号通路与MiRNA-7和MiRNA-221的增强表达之间的相互作用
5. 2,3,5,4′-Tetrahydroxy-stilbene-2- O -beta- d -glucoside induces autophagy-mediated apoptosis in hepatocytes by upregulating miR-122 and inhibiting the PI3K/Akt/mTOR pathway: implications for its hepatotoxicity [J] . Lei Yang, Wei Xing, Wang-Zhong Xiao, Pharmaceutical Biology . 2020,第1期

机译：通过上调miR-122并抑制pi3k / akt / mtor途径，诱导肝细胞的自噬介导的凋亡和抑制pi3k / akt / mtor途径，诱导肝细胞的肝细胞介导细胞凋亡：对其肝毒性的影响
6. HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway (vol 1866, pg 750, 2019) [J] . Pan Shimeng, Liu Yanqiu, Liu Qianqian, Biochimica et biophysica acta. Molecular cell research . 2019,第8期

机译：Hotair / MiR-326 / Fut6轴通过Pi3k / Akt / MTOR途径调节CD44的岩藻镜，通过PI3K / AKT / MTOR途径（第1866 Vol 1866，PG 750,2019）来促进结肠直肠癌进展
7. Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation [C] . Shigenori Nagai, Yutaka Kurebayashi, Shigeo Koyasu Inositol Phospholipid Signaling in Physiology and Disease (Conference) . 2013

机译：PI3K / AKT和MTOR复合物在Th17细胞分化中的作用
8. Genetic analysis of the PI3k/AKT/mTOR signaling pathway. [D] . Hutz, Janna Elizabeth. 2010

机译：PI3k / AKT / mTOR信号通路的遗传分析。
9. Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells [O] . Afnan H. El-Gowily, Samah A. Loutfy, Ehab M. M. Ali, 2021

机译：通过PI3K / AKT / MTOR信号传导介导的ROS依赖性凋亡和自噬疾病抑制和MCF-7乳腺癌细胞中的ROS依赖性凋亡和自噬通量抑制协同作用协同作用。在MCF-7乳腺癌细胞中灭绝的PI3K / AKT / MTOR信号传导和自噬助焊剂抑制
10. Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion [O] . Shen Qingli, Cicinnati Vito R, Zhang Xiaoyong, 2010

机译：Role of microRNa-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion
11. Experimental Analysis and Computational Modeling of Network States and Drug Responses in the PI3K/Akt/mTOR Network [R] . Albeck, J. 2010

机译：pI3K / akt / mTOR网络中网络状态和药物反应的实验分析和计算模型

Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma

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