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首页> 外文期刊>Journal of cellular physiology. >Cell mechanical microenvironment for cell volume regulation
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Cell mechanical microenvironment for cell volume regulation

机译：细胞力学微环境细胞体积监管

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摘要

Cell volume regulation, as one of the fundamental homeostasis of the cell, is associated with many cellular behaviors and functions. With the increased studies on the effect of environmental mechanical cues on cell volume regulation, the relationship between cell volume regulation and mechanotransduction becomes more and more clear. In this paper, we review the mechanisms and hypotheses by which cell maintains its volume homeostasis both in vivo and in constructed cell mechanical microenvironment (CMM) in vitro. We discuss how the growth-division regulation maintains the volume homeostasis of cells in the cell cycle and how the cell cortex/membrane tension mediates the effect of CMM (i.e., osmotic pressure, matrix stiffness, and mechanical force) on cell volume regulation. We also highlight the roles of cell volume as a perfect integrator of the downstream signals of mechanotransduction from different aspects of CMM and an effective indicator for the mechanical condition that cell confronts. This interdisciplinary perspective can provide new insight into biomechanics and may shed light on bioengineering and pathological research work. We hope this review can facilitate future studies on the investigation of the role of cell volume in mechanotransduction.
机译：细胞体积的规定,作为一个基础体内平衡的细胞,与许多相关细胞的行为和功能。增加对环境的影响机械线索细胞体积监管,细胞体积调节之间的关系转导变得越来越清晰。在本文中,我们审查的机制细胞在其体积的假设体内平衡体内和细胞构造机械微环境(CMM)体外。讨论如何growth-division监管维持细胞的体积内稳态细胞周期以及细胞皮层/膜张力调节CMM(即渗透的影响压力,刚度矩阵和机械力)细胞体积的监管。细胞体积的角色作为一个完美的积分器下游的信号转导从CMM和有效的不同方面细胞的力学条件指标面对。生物力学和提供新的见解阐明生物工程和病理研究工作。未来的研究调查的作用转导的细胞体积。

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