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首页> 外文期刊>Journal of cellular physiology. >Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats
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Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats

机译：红橙和柠檬提取物预防肾毒性赭曲霉毒素A诱导的大鼠

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摘要

In this work, we investigated the effects of red orange and lemon extract (RLE) on ochratoxin A (OTA)-induced nephrotoxicity. In particular, we analyzed the change in renal function and oxidative stress in Sprague-Dawley rats treated with OTA (0.5 mg/kg body weight, b.w.) and with RLE (90mg/kg b.w.) by oral administration. After OTA treatment, we found alterations of biochemical and oxidative stress parameters in the kidney, related to a severe decrease of glomerular filtration rate. The RLE treatment normalized the activity of antioxidant enzymes and prevented the glomerular hyperfiltration. Histopathological examinations revealed glomerular damages and kidney cortex fibrosis in OTA-rats, while we observed less severe fibrosis in OTA plus RLE group. Then, we demonstrated that oxidative stress could be the cause of OTA renal injury and that RLE reduces this effect.
机译：在这项工作中,我们调查了红色的影响橙和柠檬提取物对赭曲霉毒素A (RLE)(OTA)全身的肾毒性。分析了肾功能的变化氧化应激在Sprague-Dawley老鼠治疗与在线旅行社(0.5毫克/公斤体重,合著)和RLE(90毫克/公斤合著),口服。OTA治疗,我们发现改变生化和氧化压力参数相关的肾脏,严重减少肾小球滤过率。规范化抗氧化酶的活性和阻止肾小球反渗透法。组织病理学检查显示肾小球损害和肾脏皮质纤维化OTA-rats,当我们观察到那么严重纤维化在OTA + RLE组。OTA肾脏的氧化应激可能是原因受伤,RLE减少这种影响。

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