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首页> 外文期刊>Journal of cellular physiology. >CHIP regulates skeletal development and postnatal bone growth
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CHIP regulates skeletal development and postnatal bone growth

机译：芯片调节骨骼发展和产后骨骼生长

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摘要

C terminus of Hsc70-interacting protein (CHIP) is a chaperone-dependent and U-box containing E3 ubiquitin ligase. In previous studies, we found that CHIP regulates the stability of multiple tumor necrosis factor receptor-associated factor proteins in bone cells. In Chip global knockout (KO) mice, nuclear factor-kB signaling is activated, osteoclast formation is increased, osteoblast differentiation is inhibited, and bone mass is decreased in postnatal Chip KO mice. To determine the role of Chip in different cell types at different developmental stages, we created chip~(flox/flox) mice. We then generated Chip conditional KO mice Chip~(CMV) and Chip~(OsxER) and demonstrated defects in skeletal development and postnatal bone growth in Chip conditional KO mice. Our findings indicate that Chip conditional KO mice could serve as a critical reagent for further investigations of functions of CHIP in bone cells and in other cell types.
机译：C末端Hsc70-interacting蛋白质(芯片)一个包含E3 chaperone-dependent和U-box泛素连接酶。芯片调节多个稳定的肿瘤坏死因子receptor-associated因素在骨细胞蛋白质。(KO)小鼠,核factor-kB信号激活,增加破骨细胞的形成,,会抑制成骨细胞分化和骨质量是减少产后芯片KO小鼠。确定在不同的细胞芯片的作用类型在不同的发展阶段,我们创建芯片~(液氧/液氧)老鼠。芯片芯片~ (CMV)和条件KO小鼠芯片~ (osx)在骨骼和证明缺陷发展和产后骨骼生长的筹码有条件的KO小鼠。芯片KO小鼠可以作为条件进一步调查的关键试剂芯片的功能在骨细胞和其他细胞类型。

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