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Comparative effect sizes in randomised trials from less developed and more developed countries: meta-epidemiological assessment

机译:在随机试验比较效应的大小欠发达和较发达国家:meta-epidemiological评估

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STUDY QUESTION Do randomised trials in less developed countries give different results from those in more developed countries and, if so, to what extent?SUMMARY ANSWER Randomised trials from less developed countries occasionally show significantly different treatment effects from those from more developed countries, and on average treatment effects are more favourable in the less developed countries.WHATIS KNOWN AND WHATTHIS PAPER ADDS An increasing number of trials are performed in less developed countries with no Ipftgstanding tradition of clinical research. Discrepancies in treatment effects between trials from more developed versus less developed countries may often reflect biases as well as genuine-differences and should be taken into account when generalising evidence across different settings.
机译:研究问题在少做随机试验发达国家给予不同的结果更发达的国家,如果是这样,什么程度?欠发达国家偶尔秀治疗效果明显不同这些来自发达国家,平均治疗效果更有利欠发达国家。WHATTHIS纸添加越来越多的试验是在欠发达国家执行没有Ipftgstanding临床的传统研究。试验之间更发达和更少发达国家可能经常反映偏见应该采取的分歧以及时总结的证据不同的设置。

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