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首页> 外文期刊>Genetic testing and molecular biomarkers >CYP2C9 and CYP2C19 Allele and Haplotype Distributions in Four Mestizo Populations from Western Mexico: An Interethnic Comparative Study
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CYP2C9 and CYP2C19 Allele and Haplotype Distributions in Four Mestizo Populations from Western Mexico: An Interethnic Comparative Study

机译：CYP2C9和CYP2C19基因单体型人口分布在四个混血儿墨西哥西部:不同种族间的比较研究

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Aims: Polymorphisms in the CYP2C9 and CYP2C19 genes confer potential risk for specific adverse drug reactions and therapeutic effect failure. Their frequencies differ among ethnic groups. This study was aimed to describe the distribution of CYP2C9 and CYP2C19 alleles and haplotypes in four Mestizo populations from Western Mexico and their comparison with the reported data from other ethnic groups. Methods: The CYP2C alleles (CYP2C9*2, CYP2C9*3, CYP2C19*2, and CYP2C19*3) were genotyped using polymerase chain reaction-restriction fragment length polymorphisms analyses using DNA samples from 477 healthy Mestizo individuals of Colima (n = 100), Jalisco (n = 147), Michoacan (n = 117), and Nayarit (n = 113). Results: Frequencies ranged from 2.2-3.0% and 4.8-8.9% for CYP2C9*3 and CYP2C9*2 alleles, respectively, and 5.4-12.0% for CYP2C19*2, whereas the CYP2C19*3 allele was not found. Haplotype GACA, which harbors the loss-of-function allele CYP2C19*2, was the second most frequent (8.7%). Genetic heterogeneity between the Western Mexican populations studied here and the global population was evident (p < 0.05), except for most American populations and other Mexican Mestizo populations. Conclusion: Our findings increase the evidence for genetic variability at relevant pharmacogenetic loci and could be useful in association studies involving drugs that are substrates for CYP2C enzymes in the Western Mexican population.
机译：目的:在CYP2C9和CYP2C19多态性为特定的不良基因带来潜在风险药物反应和治疗效果的失败。他们的频率不同的民族之一。本研究旨在描述分布CYP2C9和CYP2C19等位基因和单体型从墨西哥和西部四个混血儿数量与报道的数据进行比较其他种族的人。(CYP2C9 * 2, CYP2C9 * 3, CYP2C9家族* 2,和CYP2C9家族* 3)基因分型用聚合酶链吗reaction-restriction片段长度多态性分析使用DNA样本477健康的混血儿个人科利马(n = 100),哈利斯科(n = 147),米却肯州(n = 117)、和纳亚里特州(n = 113)。从2.2 -3.0%和4.8 -8.9% CYP2C9 * 3和CYP2C9 * 2等位基因,分别为5.4 -12.0%CYP2C19 * 2,而CYP2C19 * 3等位基因不是发现。丧失等位基因CYP2C19 * 2,是第二最常见(8.7%)。墨西哥西部种群之间的研究这里和全球人口明显(p <0.05),除了大多数美国人口和其他墨西哥混血儿数量。我们的研究结果增加遗传的证据在相关的遗传位点和可变性可能是有用的在协会的研究涉及药物CYP2C酶的底物墨西哥西部人口。

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