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首页> 外文期刊>Genetic testing and molecular biomarkers >A Single-Nucleotide Polymorphism of miR-196a2T C rs11614913 Is Associated with Hepatocellular Carcinoma in the Chinese Population
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A Single-Nucleotide Polymorphism of miR-196a2T C rs11614913 Is Associated with Hepatocellular Carcinoma in the Chinese Population

机译：mir - 196的单核苷酸多态性——a2t Crs11614913与肝细胞有关中国人口的癌

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Objective: We investigated the miR-196a2T>C rs11614913 variant in the initiation and progression of hepatocellular carcinoma (HCC). Methods: A case-control research model was conducted and the genotypes of 109 HCC patients and 105 healthy controls were identified by direct sequencing. The correlation between the rs11614913 genotypes and the susceptibility to HCC was evaluated using an unconditional logistic regression model. Results: We found that 20/109 (18.3%) patients were TT homozygote, whereas 64/109 (58.8%) patients had the CT genotype, and 25/109 (22.9%) patients had the CC genotype. In control samples, the frequency of the TT homozygote was 33.3%, that of CT was 49.5%, and that of CC was 17.1%. After adjusting for age and gender by logistic regression analysis, we found significant differences in susceptibility to HCC by genotype (TT vs. CT+CC: OR=2.52, 95%CI=1.18-4.19; p<0.05). The CT and CC genotypes were more common in HCC patients compared to controls. Moreover, the CT+CC genotypes were associated with a poor HCC prognosis. Conclusions: In this study, we found that the CT+CC genotypes of rs11614913 were significantly associated with an increased risk and poor prognosis for HCC in the Chinese population.
机译：目的:我们研究了mir - 196 a2t > C在启动和rs11614913变体肝细胞癌(HCC)的进展。方法:病例对照研究模型和109名肝癌患者的基因型和105名健康对照了直接测序。rs11614913基因型和易感性肝细胞癌是评估使用无条件物流回归模型。(18.3%)患者TT纯合体,而64/109(58.8%)的患者CT基因型,和25/109(22.9%)的患者CC基因型。控制样品,TT的频率纯合体为33.3%,CT为49.5%,CC是17.1%。性别逻辑回归分析,我们发现在对肝细胞癌的易感性显著差异由基因型(CT + TT和CC: = 2.52,95%可信区间= 1.18 - -4.19;更常见的肝癌患者相比控制。与肝细胞癌预后很差。结论:在这项研究中,我们发现CT + CC基因型rs11614913明显与风险增加和贫穷中国人口肝癌的预后。

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