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首页> 外文期刊>Genetic testing and molecular biomarkers >The T Allele of MTHFR c.C677T and Its Synergism with G (Val 158) Allele of COMT c.G472A Polymorphism Are Associated with the Risk of Bipolar I Disorder
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The T Allele of MTHFR c.C677T and Its Synergism with G (Val 158) Allele of COMT c.G472A Polymorphism Are Associated with the Risk of Bipolar I Disorder

机译：T等位基因的MTHFR c.C677T及其合作与G COMT c.G472A (Val 158)等位基因多态性与风险相关联双相I型

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Aims: The aims of the present study were to investigate the association between methylenetetrahydrofolate reductase (MTHFR) c.C677T (p.A222V) and catechol-O-methyltransferase (COMT) c.G472A (p.V158M) polymorphisms and their synergism with respect to bipolar I disorder (BID). Methods: Within an ethnic Kurdish population from Western Iran the MTHFR c.C677T and COMT c.G472A polymorphisms were studied in 150 patients with BID and 149 gender-and age-matched healthy individuals using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: In the presence of MTHFR 677T allele and MTHFR TT genotype, the risk of BID was 1.44 times (p = 0.046) and 1.81-fold (p = 0.029), respectively. The frequency of COMT 472G allele compared to the A allele in cases and controls was not significant (p = 0.078); however there was a synergism between the presence of MTHFR 677T and COMT 472G alleles that increased the risk of BID by 2.58-fold (p = 0.003). Conclusions: Our findings indicate that the presence of the lower activity allele of MTHFR (677T) increased the risk of BID. In addition, the concomitant presence of the MTHFR 677T allele with the COMT 472G allele was associated with increased susceptibility to BID in our population.
机译：目的:本研究的目的是调查之间的关系methylenetetrahydrofolate还原酶(MTHFR)c.C677T (p.A222V)和catechol-O-methyltransferase c.G472A (COMT的)(p.V158M)多态性和他们合作对双相I型(报价)。在一个少数民族库尔德人口来自西方伊朗的MTHFR c.C677T和COMT c.G472A在150年患者多态性进行了研究投标和149年性别和年龄的健康使用聚合酶链个人reaction-restriction片段长度多态性(PCR-RFLP)方法。MTHFR 677 t等位基因与MTHFR TT基因型,风险投标(p = 0.046) 1.44倍和1.81倍分别(p = 0.029)。相比472 g等位基因在病例和等位基因控制不显著(p = 0.078);之间有一个合作的存在MTHFR COMT 472 g等位基因677 t和增加投标的风险增加2.58倍(p = 0.003)。结论:我们的研究结果表明MTHFR的低活动等位基因的存在(677 t)收购的风险增加。随之而来的MTHFR 677 t等位基因的存在COMT的472 g等位基因有关报价在我们的敏感性人口。

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