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首页> 外文期刊>Genetic testing and molecular biomarkers >Association Between Adiponectin Polymorphisms and the Risk of Colorectal Cancer
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Association Between Adiponectin Polymorphisms and the Risk of Colorectal Cancer

机译：脂联素多态性和之间的联系结肠直肠癌的风险

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Purpose: To discuss the association between adiponectin (ADIPOQ) gene rs2241766 and rs1501299 polymorphisms and the risk of colorectal cancer, and to analyze the role of the interaction between these two loci and environmental factors in colorectal cancer pathogenesis. Methods: The case-control study was performed with a 1:1 match. A self-designed questionnaire was used to perform a face-to-face survey with 600 new primary colorectal cancer cases confirmed by histopathology as well as 600 cases of people receiving a physical examination at the same time. The general information, lifestyle, and diet habits, etc. were collected from two groups of study subjects. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to identify ADIPOQ rs2241766 and rs1501299 genotypes. Results: After adjusting for factors such as colorectal cancer family history, body-mass index (BMI), daily sedentary time, weekly red meat intake frequency, as well regular tea drinking, conditional logistic regression analysis indicated that rs2241766 TG+GG carriers had a higher risk of colorectal cancer than TT carriers (OR=1.433, 95% CI: 1.014-1.985); rs1501299 GT+TT carriers had a lower risk of colorectal cancer than GG carriers (OR=0.723, 95% CI: 0.531-0.902). Generalized multifactor dimensionality reduction analysis showed that ADIPOQ rs2241766 and rs1501299 could have interaction with red meat intake (p=0.001). Conclusion: ADIPOQ rs2241766 and rs1501299 single nucleotide polymorphisms (SNPs) could be associated with colorectal pathogenesis and could have interactions with red meat intake. Both factors impact colorectal cancer occurrence.
机译：目的:探讨之间的关系脂联素基因(ADIPOQ) rs2241766 rs1501299多态性和结直肠癌的风险,和分析的角色交互这两个位点之间和环境因素在结直肠癌发病机制。病例对照研究进行了1:1匹配。进行面对面的调查有600新原发性结直肠癌确诊病例组织病理学以及600例接受身体检查一样时间。从两组收集饮食习惯等研究对象。reaction-restriction片段长度多态性(PCR-RFLP)是用来确定ADIPOQ rs2241766和rs1501299基因型。结肠直肠癌等因素的家庭历史,体重指数(BMI),每天久坐不动的一次,每周一次的红肉摄入频率定期喝茶,有条件的物流回归分析表明,rs2241766TG + GG运营商大肠癌的风险更高癌症比TT运营商(或= 1.433,95%置信区间CI:1.014 - -1.985);比GG运营商降低结直肠癌的风险(或= 0.723,95% CI: 0.531—-0.902)。多因素降维分析表明ADIPOQ rs2241766 rs1501299可以与红肉的摄入量(p = 0.001)。结论:ADIPOQ rs2241766和rs1501299单身核苷酸多态性(snp)与大肠癌发病机理和可能与红肉摄入量有相互作用的情况。影响结直肠癌发生的因素。

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