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首页> 外文期刊>Genetic testing and molecular biomarkers >TPOX Triallelic Genotype: An Interesting Pattern to Be Noted in Bone Marrow Transplantation Monitoring
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TPOX Triallelic Genotype: An Interesting Pattern to Be Noted in Bone Marrow Transplantation Monitoring

机译：TPOX Triallelic基因型:一个有趣的模式指出在骨髓移植监控

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Aims: TPOX triallelic genotypic pattern has been described in the setting of forensic and paternity testing but not in bone marrow transplantation (BMT) monitoring for graft engraftment. Materials and Methods: A total of 50 cases have been studied using the AmpFLSTR((R)) Identifiler (TM) polymerase chain reaction amplification kit as part of the workup of patients and donors before and after BMT at the American University of Beirut Medical Center. Results: Of the 50 studied cases, 49 showed typical allelic patterns of the variable short tandem repeats detected by the assay; however, one single patient showed a biallelic TPOX genotype in the pre-BMT specimen but a triallelic pattern in the post-BMT sample. Conclusion: Triallelic patterns of TPOX should also be considered in the context of BMT monitoring testing where misinterpretation of the allelic pattern can lead to wrong unwanted conclusions related to the graft condition and proper quantification of donor DNA.
机译：目的:TPOX triallelic基因型模式在法医的设置和描述但不是在骨髓亲子鉴定测试移植(BMT)监测贪污移植。病例研究使用AmpFLSTR ((R))Identifiler (TM)聚合酶连锁反应放大设备检查的一部分病人和捐助者BMT的之前和之后贝鲁特美国大学医疗中心。结果:研究的50例,49显示典型的等位基因模式变量的短串联重复序列分析检测到的;一个病人显示biallelic TPOXpre-BMT标本但triallelic基因型模式post-BMT样本。Triallelic TPOX的模式也应该的上下文中考虑BMT监控测试在等位的误解模式会导致错误的结论有关贪污和适当的条件量化的供体DNA。

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