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首页> 外文期刊>Genetic testing and molecular biomarkers >De Novo Produced Anti-Human Leukocyte Antigen Antibodies Relation to Alloimmunity in Patients with Chronic Renal Failure
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De Novo Produced Anti-Human Leukocyte Antigen Antibodies Relation to Alloimmunity in Patients with Chronic Renal Failure

机译：新创了反人类白细胞抗原抗体与Alloimmunity病人慢性肾功能衰竭

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Aims: Chronic renal failure causes patients to become dialysis dependent, which is exhausting for them both financially and psychologically. However, the definitive treatment of chronic renal failure is transplantation. One of the crucial factors affecting success in transplantation is the presence of anti-human leukocyte antigen (HLA) antibodies in patients. HLA alloimmunization is caused by various sensitization events such as blood transfusion, pregnancy, and transplantation. In this study, different sensitization events were compared to determine the effectiveness on the panel-reactive antibody status in female solid organ transplantation candidates based upon pregnancy. Results: When results were evaluated in terms of alloimmunization rates, 62.8%, 73.4%, and 14.9% of the patients were found to have blood transfusion, pregnancy, and rejection history, respectively. Three hundred twenty-six of the 444 women had had at least one pregnancy. Panel-reactive antibody (PRA) (class I and/or II)-positive rates were significantly higher among patients with pregnancy and blood transfusion history (43.7%) than patients with only pregnancy history (27.5%) and pregnancy and transplantation history (40%). While transplantation history significantly affects class II anti-HLA levels, blood transfusion raises class I levels. Conclusions: Solid organ transplantation appears to have the strongest HLA alloimmunization effect followed by pregnancy and blood transfusion, especially for class II HLA antigens. Patients who were sensitized by more than one sensitization event have a lower chance to have a solid organ transplantation. In this case, identification of donor-specific antibodies and the results of the cross-match tests play an important role both before and postrenal transplantation.
机译：目的:慢性肾功能衰竭病人成为依赖透析,精疲力尽为他们在经济上和心理上的。然而,明确治疗慢性移植肾功能衰竭。影响成功的关键因素移植是反人类的存在白细胞抗原(HLA)抗体的病人。HLA异源免疫是由不同引起的输血等敏感事件,怀孕和移植。不同的敏感事件进行比较确定panel-reactive上的有效性抗体在女性器官移植候选人基于怀孕。结果:当结果的评估异源免疫利率,62.8%,73.4%,14.9%病人被发现有血输血、怀孕、历史和拒绝,分别。女性有至少一个怀孕。Panel-reactive抗体(PRA)(我和/或类(二)艾滋病率显著提高患者怀孕和血液输血患者(43.7%)比历史只有怀孕(27.5%)和妊娠和历史移植的历史(40%)。移植的历史很大程度上影响二类anti-HLA水平,输血提出了一级水平。移植似乎最强的HLA其次是怀孕和异源免疫效果输血,尤其是二类HLA抗原。比一个敏感事件的机会较低实体器官移植。情况下,供体特异性抗体的识别和cross-match测试发挥的结果之前和postrenal重要作用移植。

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