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首页> 外文期刊>Genetic testing and molecular biomarkers >The Paraoxonase 1 Gene c.-108CT SNP in the Promoter Is Associated with Risk for Glioma in Mexican Patients, but Not the p.L55M or p.Q192R Polymorphisms in the Coding Region
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The Paraoxonase 1 Gene c.-108CT SNP in the Promoter Is Associated with Risk for Glioma in Mexican Patients, but Not the p.L55M or p.Q192R Polymorphisms in the Coding Region

机译：Paraoxonase 1基因c - 108 c T的SNP启动子与神经胶质瘤的风险有关墨西哥病人,但不是p.L55M或p.Q192R编码区多态性

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Aim: To evaluate the association of the paraoxonase 1 (PON1) gene polymorphisms c.-108C>T, p.L55M, and p.Q192R with the risk of glioma in Southeast Mexico. Decreased PON1 activity caused by polymorphisms has been observed in gliomas, thus supporting the theory that PON1 is involved in tumorigenesis in the brain. Methods: Sixty-seven glioma patients and 58 control individuals were included. Three PON1 polymorphisms were genotyped by real-time PCR allelic discrimination using TaqMan probes: c.-108C>T in the promoter region, p.Q192R and p.L55M, both of which were in the coding region. Allele, genotype, and haplotype frequencies were assessed in cases and controls to test for statistical associations (STATA 10.2 package). Results: Significant differences were found for the PON1 c.-108C>T polymorphism between the cases and controls. Compared to the controls the cases were more likely to be CT heterozygous (p = 0.002) or TT homozygous (p = 0.036); similarly cases were more likely to possess a T allele (p = 0.032). In contrast, the p.L55M and p.Q192R polymorphisms did not show significant differences between the glioma cases and controls (p > 0.05). Conclusion: The PON1 c.-108C>T polymorphism in the promoter region is associated with genetic risk for glioma. Conversely, p.L55M and p.Q192R polymorphisms in the coding region do not seem to have an influence in this population.
机译：目的:评估的协会paraoxonase 1 (PON1)基因多态性c - 108 c > T, p.L55M, p.Q192R的风险墨西哥东南部的神经胶质瘤。活动引起的多态性在神经胶质瘤,从而支持理论PON1参与肿瘤发生的大脑。包括58控制人。多态性被实时PCR基因分型等位基因歧视使用TaqMan探针:c - 108 c > T在启动子区域,p.Q192R和p.L55M,这两个编码区。等位基因、基因型和单体型频率评估和控制的情况下测试统计协会(占据10.2包)。结果:发现显著差异PON1 c - 108 c > T多态性之间的情况和控制。更容易被CT杂合的(p =0.002)或TT纯合子(p = 0.036);情况下更有可能拥有一个T等位基因(p =0.032)。多态性并没有显示出显著神经胶质瘤病例和控制之间的区别(p > 0.05)。多态性在启动子区域相关联神经胶质瘤的遗传风险。和p.Q192R多态性的编码区没有在这个人口产生影响。

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