...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genetic testing and molecular biomarkers >SNCA rs3822086 CT Polymorphism Increases the Susceptibility to Parkinson's Disease in a Chinese Han Population
【24h】

SNCA rs3822086 CT Polymorphism Increases the Susceptibility to Parkinson's Disease in a Chinese Han Population

机译：SNCA rs3822086 C T多态性增加了对帕金森病中国汉族人群

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Protofibrils of alpha-synuclein mediate neuronal cell death and propagate Parkinson's disease (PD). In this study, we investigated the relationship between the rs3822086 C>T polymorphism located in the fourth intron of the alpha-synuclein (SNCA) gene and susceptibility to PD in a Chinese Han population. Methods: 146 PD patients and 144 sex- and age-matched healthy individuals (control group) were selected for this study. The SNCA rs3822086 polymorphism was examined in all 300 study subjects by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The genotype and allele frequencies of the SNCA rs3822086 polymorphism showed significant differences between the PD group and control group (TT: 25.3% vs. 18.8%, p=0.035; CT+TT: 77.4% vs. 66.0%, p=0.031; T allele: 51.4% vs. 42.4%, p=0.030; respectively). Stratified analyses based on gender indicated that male PD patients exhibited higher genotype and allele frequencies of the SNCA rs3822086 polymorphism compared to healthy male controls (TT: 26.7% vs. 13.2%, p=0.011; CC+CT: 73.3% vs. 86.8%, p=0.024; T allele: 51.2% vs. 37.9%, p=0.012; respectively). Age-stratified analyses indicated that the genotype and allele frequencies of the SNCA rs3822086 polymorphism were significantly higher in PD patients older than 60 years in comparison to healthy controls (TT: 32.2% vs. 20.5%, p=0.014; CT+TT: 77.0% vs. 60.2%, p=0.017; T allele: 54.6% vs. 40.3%, p=0.008; respectively). Conclusion: Our findings demonstrate that the SNCA rs3822086 C>T polymorphism correlates with increased susceptibility to PD among the Chinese Han population.
机译：目的:原纤丝的α-突触核蛋白调解神经细胞死亡和传播帕金森氏症疾病(PD)。rs3822086 C > T之间的关系多态性位于第四基因内区α-突触核蛋白(SNCA基因和易感性PD在中国汉族人群。病人和144个性别和年龄健康个人(对照组)被选中本研究。检查所有300个研究对象的聚合酶链reaction-restriction片段长度多态性(PCR-RFLP)分析。SNCA基因型和等位基因频率rs3822086多态性表现出显著PD组之间的差异和控制集团(TT: 25.3%比18.8%,p = 0.035;比66.0%,p = 0.031;p = 0.030;性别表示,男性PD患者表现出更高的基因型和等位基因频率SNCA的rs3822086多态性相比健康男性控制(TT: 26.7%比13.2%,p = 0.011;等位基因:51.2%比37.9%,p = 0.012;Age-stratified分析表明,SNCA基因型和等位基因频率rs3822086多态性显著更高相比之下PD患者年龄超过60岁健康对照组(TT: 32.2%比20.5%,p = 0.014;等位基因:54.6%比40.3%,p = 0.008;结论:我们的研究结果表明SNCA rs3822086 C > T多态性与中国人对帕金森病的易感性增加

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号