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首页> 外文期刊>Genetic testing and molecular biomarkers >Association Between CRP Gene Polymorphisms and the Risk of Preeclampsia in Han Chinese Women
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Association Between CRP Gene Polymorphisms and the Risk of Preeclampsia in Han Chinese Women

机译：CRP基因多态性和之间的联系子痫前期的风险汉族女性

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摘要

As an inflammatory marker, C-reactive protein (CRP) has elevated expression in preeclampsia (PE), which is implicated in the pathogenesis of PE, but there has been a lack of information on the possible association between genetic variants of CRP and PE. In this study, we aimed to assess the genetic association between CRP polymorphisms and the risk of PE in Han Chinese Women. Methods: Five single-nucleotide polymorphisms of CRP, rs2794521 (T > C), rs3091244 (C > T > A), rs3093068 (C > G), rs876538 (C> T), and rs1205 (C > T) were genotyped using the Sequenom method in 181 PE patients and 203 controls. Results: The T allele frequency for rs2794521 was significantly higher in PE patients than in controls (odds ratios [OR] = 4.091; 95% confidence interval [CI]: 1.533-10.917; p = 0.002). The TT genotype of rs2794521 conferred a risk for PE (TT vs. TC + CC: OR= 4.062; 95% CI: 1.499-11.008; p = 0.003) and severe PE (TT vs. TC + CC: OR= 9.577; 95% CI: 1.267-72.397; p = 0.006). The other four polymorphic loci were not different between the groups. The CRP H2 haplotype (T-C-C-G-C) was associated with PE (OR = 2.129; 95% CI: 1.47-3.085; p < 0.001), whereas the H1 haplotype (C-C-C-G-C) offered protection (OR = 0.23; 95% CI: 0.066-0.8; p = 0.01). Conclusions: The CRP variant rs2794521 shows a strong association with PE in Han Chinese women. Pregnant women with the TT genotype of rs2794521 have higher odds of having PE, which further supports a possible role for CRP in PE.
机译：炎症标志物c反应蛋白(CRP)在子痫前期高表达(PE),涉及的发病机制体育,但一直缺乏信息可能基因变异之间的联系CRP和体育。c反应蛋白多态性的遗传关联和PE在汉族妇女的风险。5单核苷酸多态性的c反应蛋白,rs2794521 (T > C) rs3091244 (C > T >),rs3093068 (C > G), rs876538 (C > T)和rs1205 (C使用Sequenom > T)基因分型方法181年PE病人和203个对照组。等位基因频率rs2794521明显PE患者高于控制(优势比率[或]= 4.091;(CI): 1.533 - -10.917;rs2794521授予体育风险(TT和TC +答:或= 4.062;和严重的PE (TT和TC + CC:或= 9.577;1.267 - -72.397;多态位点没有不同组。与体育有关(OR = 2.129;1.47 - -3.085;(C-C-C-G-C)提供保护(OR = 0.23;置信区间:0.066—-0.8;变体rs2794521展示了一个强大的协会体育在汉族女性。TT基因型的rs2794521有更高的几率有体育,进一步支持可能的作用

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