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首页> 外文期刊>Genetic testing and molecular biomarkers >Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population
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Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population

机译：连杆和白细胞介素- 6基因之间的联系多态性与缺血性中风:一个家庭研究在中国北方汉族人群

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Numerous genetic risk factors of ischemic stroke (IS) have been reported from both candidate gene and genome-wide strategies with inconsistent results. The objective of this study was to confirm the relationship between 10 previously identified single-nucleotide polymorphisms (SNPs) and IS in the Chinese population. Methods: A family-based study was conducted in a rural area of Beijing, with a total of 227 IS families with 622 participants recruited. Both linkage and association analyses were performed, with all the sibling pairs derived from the 227 families analyzed using the sib-pair test of model-free linkage to assess linkage between SNPs and IS, with association analyses including a family-based association test (FBAT) and generalized estimating equations (GEE). Results: Nonparametric linkage analysis revealed that the rs1800796 polymorphism in the interleukin-6 (IL-6) gene is significantly linked to the small arterial occlusion (SAO) subtype (p = 0.022), while the rs7193343 polymorphism in the ZFHX3 gene is linked to IS (p = 0.002) under the dominant model. Significant allelic associations were identified between the G allele of rs1800796 and IS (p = 0.042) and the SAO subtype (p = 0.025) in the FBAT. The GEE method revealed that the G allele of rs1800796 increased IS risk by 1.55-fold (95% 95% confidence interval [CI]: 1.01, 2.37; p = 0.043) and 2.43- fold (95% CI: 1.32, 4.45; p = 0.004) in the SAO subtype in the dominant model, which correlated with the significant associations detected in the FBAT. Conclusions: In this study, we confirmed that the SNP of rs1800796 in the IL-6 gene is related to IS and the SAO subtype using different statistical approaches. These findings could contribute to identifying individuals with a high IS risk.
机译：大量的遗传风险因子的缺血性中风(是)已报告从两个候选基因和全基因组策略不一致结果。之前确认10之间的关系确认单核苷酸多态性(snp)在中国人口。家庭是在农村地区进行研究北京,共有227个家庭622名参与者招募。协会分析,所有的兄弟姐妹对来自227个家庭分析了使用sib-pair模范自由的考验联系评估之间的联系单核苷酸多态性,与协会分析包括家庭协会(FBAT)和测试广义估计方程(天啊)。非参数连锁分析显示白细胞介素- 6 rs1800796多态性(il - 6)基因明显小有关动脉闭塞(SAO)亚型(p = 0.022),虽然rs7193343 ZFHX3多态性基因与下(p = 0.002)占主导地位的模式。确定了rs1800796 G等位基因之间的(p = 0.042)和圣亚型(p =FBAT 0.025)。rs1800796的G等位基因是风险增加了1.55倍(95% 95%可信区间[CI]:1.01、2.37;1.32、4.45;占主导地位的模式,这与FBAT检测有重要联系。结论:在这项研究中,我们确认了SNP的rs1800796 il - 6基因有关和圣子类型使用不同的吗统计方法。有助于识别患者高是风险。

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