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首页> 外文期刊>Genetic testing and molecular biomarkers >Genetic Variations in the Xenobiotic-Metabolizing Enzymes CYP1A1, CYP1A2, CYP2C9, CYP2C19 and Susceptibility to Colorectal Cancer Among Turkish People
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Genetic Variations in the Xenobiotic-Metabolizing Enzymes CYP1A1, CYP1A2, CYP2C9, CYP2C19 and Susceptibility to Colorectal Cancer Among Turkish People

机译：Xenobiotic-Metabolizing基因变异酶CYP1A1 CYP1A2, CYP2C9、CYP2C9家族和对结直肠癌在土耳其人

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摘要

Cytochrome P450 (CYP) enzymes are genetically polymorphic and play key roles in the metabolism of xenobiotics. Colorectal cancer (CRC) is one of the most common malignant tumors in Turkey as well as in the world. In this study, it was aimed both to evaluate the effects of CYP variants on the susceptibility to CRC and to predict the individual response of the Turkish people to xenobiotics metabolized by CYP enzymes. For that, we assessed the association of CYP1A1, CYP1A2, CYP2C9, and CYP2C19 polymorphisms in patients with CRC in the Turkish population through a case-control study. Distributions of the variants were determined in 104 patients with CRC and 183 healthy volunteers. As results, CYP1A1 6235T/C was significantly associated with CRC risk (odds ratio [OR] = 2.53; 95% confidence interval [CI] = 0.99-6.45; p = 0.046). In a haplotype-based analysis, CYP1A1 haplotype C_(6235-A2455) might be associated with the development of CRC (OR = 2.70; 95% CI = 0.58-5.90; p = 0.046). We believe that the findings are the first results of CYP allele distributions in the Turkish population and provide an understanding of the epidemiological studies that correlate therapeutic approaches and etiology of CRC especially in Turkish patients.
机译：细胞色素P450 (CYP)酶基因多态和代谢中起重要作用外源性物质。在土耳其最常见的恶性肿瘤在世界上。评估CYP变异的影响对CRC的易感性和预测个人反应的土耳其人外源性物质代谢的CYP酶。我们评估了协会的CYP1A1、CYP1A2CYP2C9和CYP2C19多态性的病人CRC的土耳其人口通过病例对照研究。确定104年CRC患者和183健康的志愿者。与CRC风险显著相关(几率比[或]= 2.53;0.99 - -6.45;分析、CYP1A1单体型C_ (6235 - a2455)与发展有关的CRC(或=2.70;这个研究结果首次CYP的结果等位基因分布在土耳其人口并提供的理解流行病学研究相关治疗方法和CRC的病因特别是在土耳其病人。

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