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首页> 外文期刊>Genetic testing and molecular biomarkers >Association of Genetic Variation of Sodium Taurocholate Cotransporting Polypeptide with Chronic Hepatitis B Virus Infection
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Association of Genetic Variation of Sodium Taurocholate Cotransporting Polypeptide with Chronic Hepatitis B Virus Infection

机译：协会的遗传变异的钠牛磺胆酸盐协同转运多肽与慢性乙型肝炎病毒感染

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摘要

Background: Sodium taurocholate cotransporting polypeptide (NTCP) plays an important role in the enterohepatic circulation of bile acids and hepatocyte function and was recently proposed to be a functional receptor for hepatitis B virus (HBV). Objective: This study investigated the association of the functional polymorphism c.800C > T (p.S267F) (rs2296651) of the NTCP gene with HBV infection. Methods: The study included 244 patients with chronic HBV infection, 76 HBV infection resolvers, and 113 healthy controls. The polymorphism was genotyped using the polymerase chain reaction–restriction fragment length polymorphism method. Results: The distribution of the genotype and allele frequency of rs2296651 polymorphism was significantly different among the HBV patients, HBV infection resolvers, and healthy controls (p = 0.034 and p = 0.039, respectively). The frequency of genotype CT in HBV patients was significantly higher than that in healthy controls (11.9% vs. 4.4%, p = 0.026, odds ratios [OR] = 2.913, 95% confidence intervals [95% CI] = 1.097–7.738). The frequency of allele T in HBV patients was also significantly higher than that in healthy controls (5.9% vs. 2.2%, p = 0.029, OR= 2.793, 95% CI = 1.067–7.312). The frequency of genotype CT and allele T in HBV patients was higher than that in HBV infection resolvers although the difference was not significant. The genotype and allele frequency between infection resolvers and healthy controls and between HBV patients with different clinical diseases had no significant difference. Conclusion: These findings suggest that the rs2296651 polymorphism may predispose the susceptibility to and chronicity of HBV infection.
机译：背景:牛磺胆酸盐钠协同转运多肽(NTCP)中起着重要的作用胆汁酸肝肠循环和肝细胞功能和最近被提出是一个功能为乙型肝炎病毒受体(HBV)。协会的功能多态性c.800C> T (p.S267F) (rs2296651) NTCP基因乙肝病毒感染。慢性乙型肝炎病毒感染患者76乙肝病毒感染解析器,和113名健康对照组。使用的基因多态性聚合酶链reaction-restriction片段长度多态性的方法。基因型和等位基因频率的分布rs2296651多态性明显不同的乙肝病毒的患者,乙型肝炎病毒感染解析器和健康对照组(p = 0.034, p分别为= 0.039)。CT在HBV患者明显高于在健康对照组(11.9%比4.4%,p =0.026,优势比(或)= 2.913,95%的信心时间间隔(95%置信区间)= 1.097 - -7.738)。乙肝病毒T等位基因的患者也显著高于健康控制(5.9%比2.2%,p = 0.029 = 2.793,95% CI = 1.067 - -7.312)。CT和HBV患者高于T等位基因乙型肝炎病毒感染解析器虽然差异不显著。解析器和等位基因频率之间的感染健康对照组和乙肝病毒的患者之间临床疾病没有明显不同的区别。rs2296651多态性可能使乙肝病毒的易感性和长期性感染。

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