No association between COMT Val158Met polymorphism and prostate cancer risk: A meta-analysis

Zou L.-W.; Xu X.-J.; Liu T.Wang H.-Y.Fan W.-J.Wang X.-H.Zhang Z.-X.Zhai J.-X.

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No association between COMT Val158Met polymorphism and prostate cancer risk: A meta-analysis

机译：COMT Val158Met多态性之间没有联系和前列腺癌风险:一个荟萃分析

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Results from published studies on the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and prostate cancer (PCa) risk are inconsistent. To derive a more precise estimate, we performed a meta-analysis. Methods: We searched in the PubMed and Elsevier Science Direct database for studies on the association between the COMT Val158Met polymorphism and PCa. We used the odds ratio with 95% confidence interval for PCa risk, detected potential sources of heterogeneity with the Chi-square-based Q-test, performed sensitivity analysis of studies adapted to the Hardy-Weinberg equilibrium. Results: We found seven case-control studies included 2292 patients and 2158 controls. Fix-effects meta-analysis failed to explore any significant association of PCa with the genetic model and the allelic model of COMT Val158Met. We also did not detect any association in the subgroup analysis by ethnicity in all genetic models. The gene-based analysis suggested that the genetic polymorphism in COMT is not associated with PCa. Conclusions: There is no association between the COMT Val158Met polymorphism and PCa.

机译：结果研究协会出版catechol-O-methyltransferase之间(COMT的)Val158Met多态性和前列腺癌(PCa)不一致的风险。估计,我们进行了荟萃分析。我们搜索PubMed和爱思唯尔的科学直接数据库研究协会COMT Val158Met之间的多态性和主成分分析。我们使用了优势比有95%的信心间隔PCa风险,发现潜在来源Chi-square-based的异质性Q-test,灵敏度分析进行研究适应了哈迪温伯格平衡。结果:我们发现七个病例对照研究包括2292名患者和2158名对照。Fix-effects荟萃分析探索任何失败PCa与遗传的重要协会模型和COMT Val158Met的等位基因模型。也没有发现任何关联亚组分析的种族遗传模型。COMT基因多态性的不是与PCa相关联。COMT Val158Met之间的协会多态性和主成分分析。

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《Genetic testing and molecular biomarkers》 |2013年第1期|78-84|共7页
作者
Zou L.-W.; Xu X.-J.; Liu T.Wang H.-Y.Fan W.-J.Wang X.-H.Zhang Z.-X.Zhai J.-X.;
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作者单位

Department of Occupational and Environmental Health, School of Public Health, Anhui Medical University, 69 Meishan Road, Anhui Province Hefei 230032, China;

Department of Health Informatics, School of Health Administration, Anhui Medical University, Anhui Province, Hefei, China;

School of Clinical Medicine, Anhui Medical University, Anhui Province, Hefei, China;

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正文语种英语
中图分类 Q-028;
关键词
polar cap absorption; Association (Psychology); Meta-AnalysisGenetic ModelsProstate Cancer;

机译：极冠吸收;协会(心理学);Meta-AnalysisGenetic ModelsProstate癌症;

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机译：AU A San Diego 2013 : hyper TR op和IE benign E的prostate,cancer的prostate
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机译：前列腺癌：Eupdate在线发表于2017年9月28日发表（http://www.esmo.org/guidelines/genitourinary-cancers/cancer-of-the-prostate）Esmo指南委员会
8. Early‐Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT COMT COMT (rs4680) Val158Met Genotypes [J] . Lovallo William R., Cohoon Andrew J., Sorocco Kristen H., Alcoholism: Clinical and experimental research . 2019,第7期

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9. Association of self-report measures of psychosis proneness and the COMT gene Val158Met polymorphism. [D] . Schori, Efrat Sarah. 2009

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机译：Investigation of the associations of Genetic polymorphisms in Estrogen metabolism and DNa Repair with the Background Levels of abasic sites and Risk of Developing Breast Cancer

No association between COMT Val158Met polymorphism and prostate cancer risk: A meta-analysis

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