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首页> 外文期刊>Genetic testing and molecular biomarkers >Association Between Cytotoxic T-Lymphocyte-Associated Antigen 4 + 49A/G Polymorphism and Persistent Hepatitis B Virus Infection in the Asian Population: Evidence from the Current Studies
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Association Between Cytotoxic T-Lymphocyte-Associated Antigen 4 + 49A/G Polymorphism and Persistent Hepatitis B Virus Infection in the Asian Population: Evidence from the Current Studies

机译：细胞毒性之间的联系T-Lymphocyte-Associated抗原4 + 49 a / G多态性和持久的乙型肝炎病毒在亚洲人口:感染证据当前的研究

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摘要

Aims: A number of studies assessed the association between cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) + 49A/G polymorphism and persistent hepatitis B virus (HBV) infection risk. However, the results are quite contradictory. In order to obtain a more precise estimation of the relationship, a meta-analysis was performed. Methods: Pubmed, ISI Web of Knowledge, HuGE Navigator, Wanfang Database, and China National Knowledge Infrastructure were searched. Crude odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to estimate the strength of this association. Results: Six publications were included in the final metaanalysis with 1075 cases and 1321 controls for CTLA-4 + 49A/G polymorphism according to our inclusion and exclusion criteria. We observed that the CTLA-4 + 49A/G polymorphism was significantly correlated with chronic HBV infection risk (the homozygote codominant model: OR 1.67, 95% CI 1.30-2.15; the dominant model: OR 1.34, 95% CI 1.01-1.78; the recessive model: OR 1.56, 95% CI 1.24-1.96; the allele contrast model: OR 1.32, 95% CI 1.10-1.59). No publication bias was observed in this study according to Begg's funnel plot and Egger's test. Conclusion: CTLA-4 + 49A/G polymorphism is assumed to confer a higher risk for persistent HBV infection in the Asian population.
机译：目的:研究评估了协会细胞毒性T-lymphocyte-associated抗原之间4 (CTLA-4) + 49 a / G多态性和持久的乙型肝炎病毒(HBV)感染的风险。结果是相当矛盾的。获得一个更精确的估计关系,进行荟萃分析。方法:Pubmed, ISI的网络知识,巨大的导航器,Wanfang数据库,和中国知识基础设施被搜索。优势比(ORs)置信区间为95%独联体(95%)计算估计本协会的力量。出版物是包含在最后metaanalysis 1075例病例和1321例对照CTLA-4 + 49 a / G多态性根据我们包含和排除标准。CTLA-4 + 49 a / G多态性慢性乙肝病毒显著相关感染风险(纯合子共显性的模型:或1.67,95%可信区间1.30 - -2.15;1.34, 95%可信区间1.01 - -1.78;1.56, 95%可信区间1.24 - -1.96;模型:1.32,95% CI 1.10 - -1.59)。偏见是在这项研究中根据观测到的Begg的漏斗图和食叶蛾的测试。假设CTLA-4 + 49 a / G多态性赋予持续的乙型肝炎病毒感染的风险更高亚洲的人口。

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