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首页> 外文期刊>Genetic testing and molecular biomarkers >Association of genetic polymorphisms in matrix metalloproteinase-9 and coronary artery disease in the Chinese han population: A case-control study
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Association of genetic polymorphisms in matrix metalloproteinase-9 and coronary artery disease in the Chinese han population: A case-control study

机译：关联矩阵的遗传多态性metalloproteinase-9和冠状动脉疾病在中国汉族人口:病例对照研究

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摘要

Objective: Matrix metalloproteinase-9 (MMP-9) plays an important role in inflammation and matrix degradation involved in atherosclerosis and plaque rupture. The T allele of rs3918242 has been reported to lead to a high promoter activity and associate with the extent of coronary artery disease (CAD). And some studies have reported that the G allele of rs17576 might be associated with CAD. The aim of this study was to assess the association between the polymorphisms of the MMP-9 gene and CAD in the Chinese Han population. Methods: This case-control study comprised 258 CAD cases and 153 controls from the Chinese Han Population. The genomic DNA of MMP-9 was isolated from whole blood. Polymerase chain reaction-based restriction fragment length polymorphism was used to determine the rs3918242 and rs17576 genotypes in the MMP-9 gene and the total serum levels of MMP-9 were measured using enzyme-linked immunosorbent assay in both case and control groups. Results: Analysis of MMP-9 gene polymorphisms showed that the frequencies of the T allele and CT+TT genotypes of rs3918242 were significantly higher in the case group than in the control group (p0.05). The total serum level of MMP-9 was significantly higher in the case group than in the control group (p<0.05). The subjects carrying T alleles in the CAD group had higher average serum MMP-9 levels compared with CC genotypes (p<0.05). Conclusions: Our results suggest that the single-nucleotide polymorphism of rs3918242 in the MMP-9 gene is associated with CAD and high serum levels of MMP-9 are also associated with CAD in the Chinese Han population. Therefore, genetic variation of rs3918242 may participate in the development of CAD through influencing MMP-9 expression.
机译：摘要目的:矩阵metalloproteinase-9 (MMP-9)在炎症和扮演着重要的角色矩阵退化参与动脉粥样硬化和斑块破裂。据报道导致高启动子活性和副冠状动脉的程度疾病(CAD)。rs17576的G等位基因可能是相关的CAD。的多态性之间的联系MMP-9基因和CAD在中国汉族人群。方法:病例对照研究由258从中国汉族CAD病例和153例对照人口。从全血。使用限制片段长度多态性确定rs3918242 rs17576基因型MMP-9基因和总血清水平的使用酶联MMP-9测量免疫吸附试验情况和控制组。多态性显示的频率rs3918242 T等位基因和CT + TT基因型的案组显著高于对照组(p 0.05)。案组显著高于对照组(p < 0.05)。CAD组T等位基因有更高的平均水平血清MMP-9水平与CC基因型(p < 0.05)。rs3918242的单核苷酸多态性MMP-9基因与CAD和高相关血清水平的MMP-9也有关CAD在中国汉族人群。遗传变异rs3918242可能参与通过影响MMP-9 CAD的发展表达式。

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