...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genetic testing and molecular biomarkers >A candidate gene study for the association of host single nucleotide polymorphisms with liver cirrhosis risk in chinese hepatitis B patients
【24h】

A candidate gene study for the association of host single nucleotide polymorphisms with liver cirrhosis risk in chinese hepatitis B patients

机译：候选基因研究协会主办的单核苷酸多态性与肝脏中国乙肝患者肝硬化的风险

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and Aims: Recently, genetic association studies have linked a number of single nucleotide polymorphisms (SNPs) with liver fibrosis risk of hepatitis C. The present study was designed to validate the association of emerging SNPs with development of liver cirrhosis and chronicity in a Chinese population infected with hepatitis B virus (HBV). Methods: 714 Chinese subjects with persistent HBV infection (429 with evident liver cirrhosis and 285 without cirrhosis clinically or pathologically) and 280 subjects with spontaneous HBV clearance were studied. Six SNPs in five candidate genes were detected with the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) method. The distribution of each polymorphism was compared between the age-matched cirrhotic and noncirrhotic subjects, and between subjects with persistent infection and spontaneous HBV clearance. Results: The rs2679757 polymorphism of antizyme inhibitor 1 (AZIN1) gene was associated with the risk of cirrhosis (odds ratio [OR] for GG+AG versus AA=1.47, 95% confidence interval [CI]=1.08-2.01, p=0.01). So was rs886277 in the transient receptor potential cation channel subfamily M, member 5 (TRPM5) gene (OR for CC versus CT+TT=1.63, 95% CI=1.20-2.22, p=0.002). The frequencies of these two SNPs were also associated with the severity of decompensated cirrhosis based on the Child-Pugh classification. Genotype frequencies of other SNPs were not different between the cirrhotic and noncirrhotic groups. No SNPs were associated with the outcome of spontaneous HBV clearance. Conclusions: AZIN1 rs2679757 and TRPM5 rs886277 are associated with the risk of HBV-related liver cirrhosis in Chinese. The emerging SNPs warrant further clinical validation in other cohorts or ethnic groups, and could lead to mechanistic studies to reveal their contributions to fibrosis progression.
机译：背景和目的:最近,基因协会研究表明单核苷酸多态性与肝纤维化的风险肝炎c。本研究旨在验证新兴snp的协会肝硬化和慢性的发展中国的人口感染了乙肝病毒病毒(HBV)。持续的乙型肝炎病毒感染肝(429年明显肝硬化和285没有肝硬化临床或病理上)和280名受试者自发的乙肝病毒间隙进行了研究。候选基因与被检测出matrix-assisted激光解吸/电离飞行时间质谱(MALDI-TOF MS)方法。而与肝硬化之间noncirrhotic主题,与主题之间持续感染和自发的乙肝病毒间隙。antizyme抑制剂1 (AZIN1)基因有关肝硬化的风险(优势比[或]GG + AG和AA = 1.47, 95%置信区间(CI) = 1.08 - -2.01, p = 0.01)。瞬时受体电位阳离子通道亚米,成员5 (TRPM5)基因(或CC与CT + TT = 1。63,95% CI = 1 . 20-2。22,p = 0.002)。这两个单核苷酸多态性也的频率与代偿失调的严重程度有关基于儿童肝硬化分类。其他单核苷酸多态性基因型的频率肝硬化和noncirrhotic之间的不同组。自发的乙肝病毒清除。rs2679757和TRPM5 rs886277相关联与乙型肝炎病毒有关的肝癌肝硬化的风险中国人临床验证与不同群体或民族组,并可能导致机械的研究揭示他们对纤维化的贡献进展。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号