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首页> 外文期刊>Genetic testing and molecular biomarkers >Determination of Hepatitis C Virus Genotypes in Pruritus Patients in Saudi Arabia
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Determination of Hepatitis C Virus Genotypes in Pruritus Patients in Saudi Arabia

机译：丙型肝炎病毒基因型的确定在沙特阿拉伯瘙痒的病人

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The main objective of this study was to estimate the prevalence of Hepatitis C virus (HCV) genotypes in 56 pruritus patients and 50 healthy blood donors on the basis of clinical and laboratory investigations. Both demographic and clinical data were collected from each subject after obtaining informed consent and approval from an ethics committee. Ten milliliters of venous blood was collected from fasting patients (8–10 h) and serum was used for aspartate transaminase and alanine transaminase tests, anti-HCV antibody testing, HCV-RNA polymerase chain reaction screening, and genotyping analysis. HCV was found to be significantly predominant over HBV infection among the pruritus patients ( p < 0.001). Twelve pruritus patients (21.42%) were positive for anti-HCV antibodies and nine of them were confirmed positive for HCV RNA presence. Of the two major genotypes revealed, genotype 4 was found to be significantly predominant over the mixed genotype, that is, 4a/c + 3a ( p < 0.001). Subtyping results showed that a significant majority of the type 4 were of the HCV subtype 4a (five patients), followed by 4c (two patients) and 4b genotypes (one patient) and mixed genotype 4a/c + 3a (one patient). Results of this prospective study indicated the significant association between pruritus and HCV infection. HCV genotype 4 is the most predominant genotype among the pruritus patients and warrants larger studies in different ethnicities to find the molecular association between HCV genetic variants and pruritus.
机译：本研究的主要目的是估计丙型肝炎病毒(HCV)的患病率基因型在56瘙痒患者和50名健康临床和献血者的基础上实验室调查。临床资料收集从每个主题在获得知情同意和批准伦理委员会。从禁食患者静脉血收集(8 - 10小时)和血清天冬氨酸氨基转移酶、丙氨酸氨基转移酶检测,anti-HCV抗体测试,HCV-RNA聚合酶连锁反应筛选和基因分型分析。主要在乙型肝炎病毒感染的瘙痒患者(p < 0.001)。(21.42%) anti-HCV抗体阳性和9的丙肝病毒确认为阳性RNA的存在。显示,基因型4被发现明显的混合基因型,4 a / c + 3 (p < 0.001)。子类型化的研究结果表明,一个重要的大多数类型4 4丙肝病毒亚型(5名患者),其次是4 c(2例)和4 b基因型(一个病人)和混合基因型4 a / c + 3(1例)。前瞻性研究表明显著瘙痒和丙肝病毒感染之间的联系。丙肝病毒基因型4是最主要的基因型瘙痒的病人和权证大在不同种族的研究发现分子丙肝病毒基因之间的联系变异和瘙痒。

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