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首页> 外文期刊>Genetic testing and molecular biomarkers >JAK1 gene polymorphisms are associated with the outcomes of hepatitis B virus infection, but not with α interferon therapy response in a Han Chinese population
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JAK1 gene polymorphisms are associated with the outcomes of hepatitis B virus infection, but not with α interferon therapy response in a Han Chinese population

机译：JAK1基因多态性与相关联乙型肝炎病毒感染的结果,但不是汉族与α干扰素治疗反应中国人口

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Janus kinase 1 (JAK1) is a key member in the interferon (IFN) signaling pathway. Recent studies suggested single-nucleotide polymorphisms (SNPs) in IFN pathway genes are associated with outcomes of hepatitis B virus (HBV) infection and response to IFNα therapy. The aim of the study is to investigate whether SNPs in JAK1 were associated with outcomes of HBV infection and response to IFNα therapy. Methods: We enrolled 395 chronic hepatitis B (CHB) patients and 251 subjects with the inactive carrier state, and 256 CHB patients who received IFNα treatment, with therapy efficacy evaluated. Twelve SNPs: rs310227, rs7531799, rs7546545, rs17127174, rs3790541, rs10493373, rs2780898, rs310247, rs310196, rs2780895, rs4244165, and rs17127024 in JAK1, which could represent all SNPs with minor allele frequency >0.2 recorded in the HapMap database were genotyped using a polymerase chain reaction-restriction fragment length polymorphism protocol and the TaqMan method. Results: SNP rs17127024 was associated with outcomes of HBV infection in an allele frequency (p=0.014) and genotype distributions (p=0.031), while SNP rs4244165 was associated with outcomes of HBV infection only in genotype distributions (p=0.008). There were no significant differences in allele frequencies and genotype distributions of these SNPs between the response group and the nonresponse group to IFNα therapy. Conclusions: SNPs rs4244165 and rs17127024 in JAK1 were associated with outcomes of HBV infection, but not with response to IFNα therapy.
机译：Janus激酶1 (JAK1)是一个关键的成员干扰素(IFN)信号通路。有研究表明单核苷酸多态性(单核苷酸多态性)干扰素通路相关的基因乙型肝炎病毒(HBV)感染的结果对干扰素α治疗的反应。调查是否在JAK1 snp与乙型肝炎病毒感染的结果对干扰素α治疗的反应。395慢性乙型肝炎(慢乙肝)患者和251主题活动载体的状态,和256年慢性乙肝患者接受干扰素α治疗,治疗疗效评估。rs310227、rs7531799 rs7546545 rs17127174,rs3790541、rs10493373 rs2780898 rs310247,rs310196、rs2780895 rs4244165, rs17127024JAK1,代表所有与小单核苷酸多态性等位基因频率> 0.2记录在人类基因组单体型图数据库使用聚合酶链基因分型reaction-restriction片段长度多态性协议和TaqMan方法。rs17127024与乙肝病毒的结果感染一个等位基因频率(p = 0.014)基因型分布(p = 0.031), SNPrs4244165与乙肝病毒的结果只感染基因型分布(p = 0.008)。在等位基因频率和基因型分布这些snp组和之间的反应nonresponse组干扰素α治疗。单核苷酸多态性rs4244165和rs17127024 JAK1与乙型肝炎病毒感染的结果,但是不是用干扰素α治疗的反应。

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