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首页> 外文期刊>Genetic testing and molecular biomarkers >Association Between Tumor Necrosis Factor-α-308G/A Polymorphism and Obstructive Sleep Apnea: A Meta-Analysis
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Association Between Tumor Necrosis Factor-α-308G/A Polymorphism and Obstructive Sleep Apnea: A Meta-Analysis

机译：协会肿瘤坏死因子-α-308 g / A多态性和阻塞性睡眠呼吸暂停:荟萃分析

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摘要

Background and objective: The tumor necrosis factor (TNF)–α-308G/A polymorphism has been implicated in susceptibility to obstructive sleep apnea (OSA). However, results from previous studies are inconsistent. A systematic review and meta-analysis of the published studies was performed to investigate this association. Method: We searched PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Weipu databases for published studies evaluating the association between - 308G/A polymorphism and OSA. Data were extracted using standardized forms and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results: Four case–control studies involving a total of 419 cases and 460 controls were included in the meta-analysis. Combined data indicated that individuals carrying the - 308A allele had a 65% increased risk of developing OSA when compared with the GG homozygotes (OR = 1.65, 95% CI = 1.02–2.68, p = 0.04). In adults, the risk was even higher, elevated by 100% (OR = 2.00, 95% CI = 1.26–3.18, p = 0.003). Conclusion: The TNF-α- 308G/A polymorphism contributes to the risk of OSA, especially in adults.
机译：背景和目的:肿瘤坏死因子(TNF) -α-308 g / A多态性涉及对阻塞性睡眠的易感性呼吸暂停综合症)。研究不一致。荟萃分析的研究发表调查本协会执行。方法:我们搜索PubMed、Embase、Web科学、中国国家知识基础设施(CNKI),维普数据库已发表的研究评估之间的联系- 308 g / A多态性和阻塞性睡眠呼吸暂停综合症。标准化的形式和优势比(ORs)为95%置信区间(CIs)计算。结果:四个病例对照研究涉及共有419例病例和460例对照被包括在内荟萃分析。个人携带- 308一个等位基因患阻塞性睡眠呼吸暂停综合症的风险增加65%相比GG比如(或= 1.65,95%CI = 1.02 - -2.68, p = 0.04)。甚至更高,升高100%(或= 2.00,95%CI = 1.26 - -3.18, p = 0.003)。肿瘤坏死因子-α- 308 g / A多态性有助于阻塞性睡眠呼吸暂停综合症的风险,特别是成年人。

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