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MCP-1 and CCR2 Gene Variants and the Risk for Osteoporosis and Osteopenia

机译：MCP-1 CCR2基因变异和面临的风险骨质疏松症和骨质疏松

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Aim: In this study, we investigated whether monocyte chemotactic protein 1 (MCP-1) and CC chemokine receptor 2 (CCR2) gene polymorphisms account for an increased risk of osteoporosis or osteopenia. Methods: Three hundred three postmenopausal women, 80 osteoporotic, 123 osteopenic, and 100 unrelated age-matched healthy controls, were included in the study. Genotyping of MCP-1 A2518G and CCR2 V64I gene polymorphisms were detected by PCR-RFLP. Results: We, for the first time, demonstrated the positive association of MCP-1 GG, CCR2 Val/Ile, and CCR2 Val + genotype with osteoporosis risk. However, CCR2 Ile/Ile genotype frequencies were high in the control group compared with those of the patients with osteoporosis and osteopenia. Haplotype analysis confirmed the association of MCP-1/CCR2 gene variants with osteopenia and revealed that the frequency of MCP-1 A:CCR2 Val haplotype was significantly higher in patients when compared with controls. Conclusions: In conclusion, our findings have suggested that MCP-1 and CCR2 gene variants were risk factors for osteoporosis and osteopenia.
机译：目的:在这项研究中,我们调查是否单核细胞趋化蛋白1 (MCP-1)和CC趋化因子受体2 (CCR2)基因多态性占增加骨质疏松症的风险骨量减少。80绝经后妇女骨质疏松性,123年osteopenic, 100的同龄健康无关控制,包括在研究。的MCP-1 A2518G和CCR2 V64I基因多态性被PCR-RFLP检测。第一次展示了积极的协会MCP-1 GG, CCR2 Val / Ile, CCR2 Val +基因型与骨质疏松症的风险。Ile / Ile基因型频率高对照组相比病人骨质疏松症和骨质疏松。分析证实MCP-1 / CCR2协会基因变异与骨量减少和显示的频率MCP-1答:CCR2 Val单体型更高的病人相比与控制。研究结果表明MCP-1和CCR2基因变异是骨质疏松症的危险因素骨量减少。

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