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首页> 外文期刊>Genetic testing and molecular biomarkers >CYP2D6 Genotyping in Natives and Immigrants from the Emilia-Romagna Region (Italy)
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CYP2D6 Genotyping in Natives and Immigrants from the Emilia-Romagna Region (Italy)

机译：CYP2D6基因分型在原住民和移民选票地区(意大利)

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摘要

Pharmacogenetic testing of drug metabolizing enzyme polymorphisms provides an important tool to improve prescribing decisions, avoiding therapeutic failure and adverse drug reactions. Cytochrome P450 2D6 isoform plays an important role in the metabolism of about 20%–25% of widely used clinical drugs. Interethnic differences in allele frequency distribution of the CYP2D6 gene are well established, but interethnic admixture, introducing variations in population ancestry and resulting in distinct levels of population structure, should be acknowledged in pharmacogenomic studies to avoid inappropriate extrapolation of CYP2D6 data. The aim of the present research was to characterize CYP2D6 polymorphism in a random sample of 122 natives and 175 immigrants from Africa, Asia, and South America living in the Emilia-Romagna region (Italy), considering the present scenario of immigration and back migration events, which is a source of admixture. The results are today consistent with the known interethnic genetic variation, but the observed significant divergence between natives and Africans or South-East Asians predicts that admixture will reshape the population structure and the native metabolic ratio curve requiring, for drug prescription and pharmacogenetics studies, an interdisciplinary approach applied in an appropriate biogeographical and anthropological frame.
机译：药物代谢的遗传测试酶多态性提供了一个重要的工具提高处方决策,避免治疗失败和药物不良反应。细胞色素P450 2 d6同种型中扮演一个重要的大约20%的新陈代谢作用广泛的-25%临床药物使用。CYP2D6基因的等位基因频率分布已经很成熟,但不同种族间的掺合料,引入人口祖先和变化导致不同程度的人口结构,应该承认药物基因组学研究,以避免不合适的CYP2D6数据的外推。目前的研究是CYP2D6的特点多态性在随机抽取的122名居民和175年移民非洲、亚洲、和南美国生活在选票的地区(意大利),考虑到目前的情况移民和移民事件,这是一个掺合料的来源。符合已知的不同种族间的基因变化,但观察到的重要当地人和非洲人或之间的分歧东南亚各国预测,掺合料将人口结构和本机重塑药物代谢率曲线要求处方药物基因学研究,应用在一个跨学科的方法适当的生物地理学和人类学框架。

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