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首页> 外文期刊>Genetic testing and molecular biomarkers >Tumor Necrosis Factor Alpha 308 G/A Polymorphism and Hepatocellular Carcinoma Risk in a Chinese Population
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Tumor Necrosis Factor Alpha 308 G/A Polymorphism and Hepatocellular Carcinoma Risk in a Chinese Population

机译：肿瘤坏死因子α- 308 G / A多态性和肝细胞癌风险在中国人口

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Background: The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. Tumor necrosis factor alpha (TNF-a) is a cytokine that may act as an endogenous tumor promoter. The association between TNF-a 308 G/A polymorphism and HCC risk remains unclear. Aim: The aim of this study was to investigate the association between TNF-a 308 G/A polymorphism and HCC risk in a Chinese population. Methods: The study population consisted of 88 patients with documented HCC and 88 healthy controls. The gene polymorphism of TNF-a was analyzed by polymerase chain reaction–restriction fragment length polymorphism assay. Results: HCC patients had a significantly lower frequency GG (odds ratio = 0.36; 95% confidence interval = 0.13, 0.94; p = 0.04) and G allele (odds ratio = 0.58; 95% confidence interval = 0.37, 0.90; p = 0.01) than healthy controls. When stratifying for tumor size and cirrhosis, no statistically significant results were found. Conclusion: This study suggested that TNF-a -308GG and G allele were associated with a modest decrease in the risk of HCC in Chinese population.
机译：背景:易感性的遗传基础肝细胞癌(HCC)是不佳理解。是一种细胞因子,可以作为一种内源性肿瘤吗启动子。多态性和肝癌风险尚不清楚。本研究的目的是调查TNF-a 308 G / A多态性之间的联系中国人口和肝癌的风险。研究人口由88名患者有肝细胞癌和88名健康对照组。TNF-a的基因多态性进行了分析聚合酶链reaction-restriction片段长度多态性分析。发生频率明显降低GG(几率率= 0.36;0.94;95%置信区间= 0.37,0.90;比健康对照组。大小和肝硬化,没有统计学意义结果被发现。建议-308年TNF-a gg和G等位基因与适度减少相关的风险中国人口的肝癌。

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