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首页> 外文期刊>Genetic testing and molecular biomarkers >Testing the Children: Do Non-Genetic Health-Care Providers Differ in Their Decision to Advise Genetic Presymptomatic Testing on Minors? A Cross-Sectional Study in Five Countries in the European Union
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Testing the Children: Do Non-Genetic Health-Care Providers Differ in Their Decision to Advise Genetic Presymptomatic Testing on Minors? A Cross-Sectional Study in Five Countries in the European Union

机译：测试孩子:做非遗传性医疗供应商有不同的决策建议对未成年人发生前症状的基因测试?横断面研究的五个国家欧盟

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Within Europe many guidelines exist regarding the genetic testing of minors. Predictive and presymptomatic genetic testing of minors is recommended for disorders for which medical intervention/ preventive measures exist, and for which early detection improves future medical health. Aim: This study, which is part of the larger 5th EU-framework "genetic education" (GenEd) study, aimed to evaluate the self-reported responses of nongenetic health-care providers in five different EU countries (Germany, France, Sweden, the United Kingdom, and the Netherlands) when confronted with a parent requesting presymptomatic testing on a minor child for a treatable disease. Methods: A cross-sectional study design using postal, structured scenariobased questionnaires that were sent to 8129 general practitioners (GPs) and pediatricians, between July 2004 and October 2004, addressing self-reported management of a genetic case for which early medical intervention during childhood is beneficial, involving a minor. Results: Most practitioners agreed on testing the oldest child, aged 12 years (81.5% for GPs and 87.2% for pediatricians), and not testing the youngest child, aged 6 months (72.6% for GPs and 61.3% for pediatricians). After multivariate adjustment there were statistical differences between countries in recommending a genetic test for the child at the age of 8 years. Pediatricians in France (50%) and Germany (58%) would recommend a test, whereas in the United Kingdom (22%), Sweden (30%), and the Netherlands (32%) they would not. Conclusion: Even though presymptomatic genetic testing in minors is recommended for disorders for which medical intervention exists, EU physicians are uncertain at what age starting to do so in young children.
机译：在欧洲许多准则存在有关未成年人的基因测试。未成年人的基因测试发生前症状推荐用于医疗的障碍干预/预防措施存在,早期检测提高了未来医疗健康。大5日向“遗传教育”(基因)的研究,旨在评估nongenetic医疗的自我报告的反应供应商在五个不同的欧盟国家(德国、法国、瑞典、英国、和荷兰)面对父母要求测试发生前症状轻微孩子对于一个治疗的疾病。使用邮政横断面研究设计,结构化scenariobased问卷发送到8129年全科医生(GPs)儿科医生,在2004年7月和10月之间2004年,解决自我管理基因早期医学干预的情况儿童时期是有益的,涉及轻微的。测试最大的孩子,12岁(81.5%)在GPs和87.2%的儿科医生),不是测试最小的孩子,年龄在6个月(72.6%GPs和61.3%的儿科医生)。多元调整统计推荐一个国家之间的区别基因测试8岁的孩子。儿科医生在法国(50%)和德国(58%)推荐一个测试,而在美国英国(22%)、瑞典(30%),和荷兰(32%)他们不会。基因检测在未成年人发生前症状推荐用于医疗的障碍欧盟干预存在,医生是不确定的在什么年龄开始在年幼的孩子会这样做。

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