MTHFR 677TT Alone and IRF6 820GG Together with MTHFR 677CT, but Not MTHFR Al298C, Are Risks for Nonsyndromic Cleft Lip with or without Cleft Palate in an Indian Population

Akhtar Ali; Subodh Kumar Singh; Rajiva Raman

首页> 外文期刊>Genetic testing and molecular biomarkers >MTHFR 677TT Alone and IRF6 820GG Together with MTHFR 677CT, but Not MTHFR Al298C, Are Risks for Nonsyndromic Cleft Lip with or without Cleft Palate in an Indian Population

【24h】

MTHFR 677TT Alone and IRF6 820GG Together with MTHFR 677CT, but Not MTHFR Al298C, Are Risks for Nonsyndromic Cleft Lip with or without Cleft Palate in an Indian Population

机译：MTHFR 677 tt孤独和IRF6 820一起ggMTHFR 677 ct,但不是MTHFR Al298C,风险Nonsyndromic唇裂有或没有间隙在一个印度人口味

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

To determine the association of three SNPs, IRF6 G820A, MTHFR C677T, and MTHFR Al298C, with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in an Indian population. Method: A total of 323 NSCL/P patients, 116 of their mothers, 108 of their fathers, and 214 normal controls have been examined for the above three SNPs. Result: Frequency of IRF6 GG was 65% in controls, 78% in cases, 84% in case-fathers, and 80% in case-mothers. MTHFR 677T homozygosity was lower than 1% in controls and unaffected parents, while in the group of probands it was much higher (3.4%; OR 4.30). The frequency of CT genotype was also high in the cases and case-mothers (OR 1.89 and 2.2, respectively). MTHFR Al298C did not reveal a statistically significant deviation in allele and genotype frequencies. Conclusion: While MTHFR 677T homozygotes show a significant association with NSCL/P, heterozygotes 677CT are minor risk factors. MTHFR Al298C does not show a risk in any combination of alleles. IRF6 820GG too forms a minor risk. However, combined genotypes IRF6 GG/MTHFR 677CT together form greater risk for NSCL/P.

机译：确定协会三个单核苷酸多态性,IRF6G820A, MTHFR C677T和MTHFR Al298C,nonsyndromic唇裂有或没有间隙口味(NSCL / P)在一个印度人。总共有323 NSCL / P病人,116的他们列祖的母亲,108年,214正常已经检查了上述三个控件单核苷酸多态性。控制,78%的病例中,84%在case-fathers,case-mothers的80%。低于1%,控制和影响的父母,而在群渊源者高得多(3.4%;还在病例和case-mothers(或1.89和2.2,分别)。揭示了统计上显著的偏差等位基因和基因型频率。而MTHFR 677 t该显示显著协会与NSCL / P,杂合子677 ct次要危险因素。风险等位基因的任意组合。也形成了一个小的风险。基因型IRF6 GG / MTHFR 677 ct共同构成更大的风险NSCL / P。

著录项

来源
《Genetic testing and molecular biomarkers》 |2009年第3期|355-360|共6页
作者
Akhtar Ali; Subodh Kumar Singh; Rajiva Raman;
展开▼
作者单位

Centre for Genetic Disorders, Banaras Hindu University, Varanasi, India.;

G.S. Memorial Plastic Surgery Hospital and Trauma Centre, Varanasi, India.;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
IRF6 gene; Cleft Palate; HomozygoteAllelesCleft LipIndiansproband;

机译：IRF6基因;腭裂;HomozygoteAllelesCleft;

相似文献

外文文献

1. Association of Single Nucleotide Polymorphisms in IRF6 and TGFA Genes With Nonsyndromic Cleft Lip With Or Without Cleft Palate in Chinese Patients [J] . Ya Shen, Yugui Cui, Weidong Wan, 南京医科大学学报：英文版 . 2009,第001期
2. Association of Single Nucleotide Polymorphisms in IRF6 and TGFA Genes With Nonsyndromic Cleft Lip With Or Without Cleft Palate in Chinese Patients [J] . Ya Shen, Yugui Cu, Weidong Wan, 生物医学研究杂志（英文版） . 2009,第001期
3. Genome-wide and Interaction Linkage Scan for Nonsyndromic Cleft Lip with or without Cleft Palate in Two Multiplex Families in Shenyang,China [J] . YUN WANG, XIN LI, WEN-LI ZHU, 生物医学与环境科学：英文版 . 2010,第005期
4. Genome-wide and Interaction Linkage Scan for Nonsyndromic Cleft Lip with or without Cleft Palate in Two Multiplex Families in Shenyang,China [J] . YUN WANG, XIN LI, WEN-LI ZHU, 生物医学与环境科学（英文版） . 2010,第005期
5. The Association between Folate Pathway Genes and Cleft Lip With or Without Cleft Palate in a Chinese Population [J] . JIN Ling Ling, CHEN Er Jun, HOU Wei, 生物医学与环境科学（英文版） . 2015,第002期
6. MTHFR 677TT Alone and IRF6 820GG Together with MTHFR 677CT, but Not MTHFR A1298C, Are Risks for Nonsyndromic Cleft Lip with or without Cleft Palate in an Indian Population [J] . Akhtar Ali, Subodh Kumar Singh, Rajiva Raman Genetic Testing . 2009,第3期

机译：在印度人群中，单独的MTHFR 677TT和IRF6 820GG与MTHFR 677CT一起使用，而不是MTHFR A1298C，是患有或不患有without裂的非综合征性唇裂的风险
7. The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure. [J] . Koupepidou P, Deltas C, Christofides TC, International angiology: A journal of the International Union of Angiology . 2005,第3期

机译：塞浦路斯患者的MTHFR 677TT和677CT / 1298AC基因型可能导致高血压肾硬化和慢性肾功能衰竭。

MTHFR 677TT Alone and IRF6 820GG Together with MTHFR 677CT, but Not MTHFR Al298C, Are Risks for Nonsyndromic Cleft Lip with or without Cleft Palate in an Indian Population

摘要

著录项

相似文献

相关主题

期刊订阅