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No Association Between Bone Mineral Density and Transforming Growth Factor Beta Gene T 861-20_c Polymorphism in Turkish Postmenopausal Women

机译:骨矿物质密度和之间没有联系转化生长因子β基因T 861 - 20 - _c多态性在土耳其的绝经后妇女

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摘要

The aim of the study was to examine whether the TGF-131 T S61-20- C gene polymorphism might be useful in identifying individuals with increased susceptibility to postmenopausal bone loss within the Turkish women population. T861-20_C polymorphism was genotyped in 616 postmenopausal women selected from the Turkish population: 311 postmenopausal osteoporotic women (OP) aged 45-65 years (mean age 58 years) and a control group (CG) of 305 postmenopausal women in the same age range (mean age 53 years) with normal bone mineral density. We have not found any significant differences in the frequency of the individual genotypes between the osteoporotic and control groups. The distribution of the T861-20-C genotypes was for Lumbar spine, CC, 74.0% in OP, 75.1% in CG; TC, 24.1% in OP, 23.9% in CG; TT, 1.9°/0 in OP, 1.0% in CG; and for femoral neck, CC, 76.8% in OP, 72.8% in CG; TC, 22.1% in OP, 25.5% in CG; TT 1.1% in OP, 1.7% CG. T861-20-C polymorphism was not found to be associated with bone mineral density in postmenopausal Turkish women. It was argued that this will be a pioneering study for the future research and therapies.
机译:这项研究的目的是检查是否tgf - 131 T S61-20 - C基因多态性用于识别患者增加对绝经后骨质疏松土耳其妇女人口。多态性在616名绝经后的基因分型女性选择从土耳其人口:311绝经后骨质疏松(OP) 45 - 65岁的女性年(平均年龄58岁)和对照组(CG) 305绝经后妇女的年龄相同范围(平均年龄53岁)与正常骨矿物密度。显著差异的频率骨质疏松性和之间的个体的基因型对照组。CC基因型是腰椎,74.0%在OP,在CG 75.1%;在CG在OP 1.9°/ 0,1.0%;在CG在OP CC, 76.8%, 72.8%;在CG 25.5%;多态性不存在相关在土耳其绝经后骨矿物质密度女性。开拓未来的研究和学习疗法。

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