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首页> 外文期刊>Genetic testing and molecular biomarkers >Estrogen Receptor Beta Gene Variant Is Associated with Vascular Dementia in Elderly Women
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Estrogen Receptor Beta Gene Variant Is Associated with Vascular Dementia in Elderly Women

机译：雌激素受体β基因相关联血管性痴呆老年妇女

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摘要

Alzheimer's disease (AD) and vascular dementia (VaD) are the main causes of dementia. Postmenopausal estrogen deficiency was suggested as a contributor to cognitive decline; however, replacement therapy failed to prove beneficial in its prevention or therapy. Sequence variants in the estrogen receptor alpha gene (ESR1) and beta gene (ESR2) may alter the effects of estrogen. Methods: This is a case—control association study of sporadic AD, VaD, and single-nucleotide polymorphisms in ESR1 (rs2234693 and rs9340799), the TA dinucleotide repeat in the ESR1 promoter, and the rs4986938 single-nucleotide polymorphism in ESR2. Two hundred forty-six women (118 AD, age 83 ± 7; 60 VaD, age 82 ± 6; and 68 cognitively intact, age 81 ± 7) residing in nursing homes were studied. The association of genotypes and AD or VaD was determined by logistic regression analysis adjusted for age and ethnic origin. Results: An association of VaD and ESR2 rs4986938 was found. Carriers of each A allele had a 1.7 increased risk compared to carriers of the G allele (odds ratio 1.71, 95% confidence interval 1-2.95). The ApoE E4 allele was associated with AD (odds ratio 3.35, confidence interval 1.44-7.82), but not with VaD. No association of AD or VaD with ESR1 genotypes or haplotypes was detected. Conclusions: The ESR2 rs4986938 polymorphism is associated with susceptibility for VaD in elderly Jewish women. These results need to be confirmed in replicate studies in other populations.
机译：阿尔茨海默病(AD)和血管性痴呆(VaD)是老年痴呆的主要原因。绝经后雌激素缺乏是建议作为一个贡献者认知能力下降;替代疗法未能证明是有益的它的预防或治疗。雌激素受体α基因(ESR1)和β基因(ESR2)可能改变雌激素的影响。方法:这是一个病例对照研究协会零星的广告,和监督,单核苷酸在ESR1多态性(rs2234693 rs9340799),助教二核苷酸重复ESR1启动子,和rs4986938单核苷酸多态性在ESR2。83±7;完好无损,年龄81±7)居住在疗养院进行了研究。或通过由逻辑回归分析调整年龄和种族起源。结果:协会的监督和ESR2 rs4986938被发现。相比风险增加运营商的G等位基因(优势比为1.71,95%置信区间1 - 2.95)。广告(优势比3.35,置信区间1.44 - -7.82),但不是和监督。广告或VaD ESR1基因型或单检测到。多态性与易感性相关老犹太妇女和监督。需要确认的复制研究其他人群。

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