Factor V Leiden and the Risk of Venous Thrombosis, Myocardial Infarction, and Stroke: A Case-Control Study in Venezuela

Carolina I. Pestana; Argimiro Torres; Susana BiancoMaria J. RojasCarlos MendezJose L. LopezNorma B. de BoschAntonietta Porco

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Factor V Leiden and the Risk of Venous Thrombosis, Myocardial Infarction, and Stroke: A Case-Control Study in Venezuela

机译：因子V莱顿和静脉血栓形成的风险,心肌梗死和中风:病例对照研究在委内瑞拉

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The most common genetic defect associated with deep vein thrombosis (DVT) is a mutation in the Factor V gene (G1691A), known as Factor V Leiden (FVL). We investigated the genotypes for FVL in 571 individuals in Venezuela: 208 patients with DVT, 175 patients with acute myocardial infarction, 54 patients with stroke, and 134 control subjects. Our results showed in the population analyzed here that the FVL was associated with a fourfold increase in the risk for DVT (odds ratio, 4.24; 95% confidence interval, 1.35-14.79); particularly, women carriers showed a 6.5-fold increase in the risk for DVT. No relation was observed between the presence of FVL and the risk for acute myocardial infarction or stroke. In conclusion, a clear association between the FVL mutation and DVT was observed in the population analyzed in Venezuela. These results are in agreement with those found in other populations with different ethnic backgrounds.

机译：最常见的基因缺陷有关深静脉血栓形成(DVT)的突变因子V基因(G1691A),称为因子V莱顿(FVL)。571人在委内瑞拉:208患者深静脉血栓形成,175患者急性心肌梗塞、中风患者54和134控制对象。这里人口分析FVL风险增加四倍深静脉血栓形成(优势比,4.24;区间1.35 - -14.79);航空公司的风险会增加6.5倍深静脉血栓形成。FVL和急性心肌的风险梗死和中风。FVL突变和深静脉血栓形成之间的联系人群中观察分析了委内瑞拉。这些结果是在协议与发现在其他人群与不同的民族背景。

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《Genetic testing and molecular biomarkers》 |2009年第4期|537-542|共6页
作者
Carolina I. Pestana; Argimiro Torres; Susana BiancoMaria J. RojasCarlos MendezJose L. LopezNorma B. de BoschAntonietta Porco;
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作者单位

Laboratorio de Genetica Molecular Humana B, Departamento de Biologia Celular, Universidad Simon Bolivar, Caracas, Venezuela;

llospital Dr. Miguel Perez Carreno, Unidad de Cuidados Coronaries, Caracas, Venezuela;

Laboratorio de Hematologia, Banco Municipal de Sangre, Caracas, Venezuela;

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正文语种英语
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factor V Leiden; controlled study; Acute Myocardial InfarctionThrombosisVenezuelaCase-Control Studies;

机译：因子V莱顿;对照研究;急性心肌InfarctionThrombosisVenezuelaCase-Control研究;

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Factor V Leiden and the Risk of Venous Thrombosis, Myocardial Infarction, and Stroke: A Case-Control Study in Venezuela

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