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首页> 外文期刊>Genetic testing and molecular biomarkers >Distribution of Cytokine Gene Polymorphisms in the General Lebanese Population: The First Report
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Distribution of Cytokine Gene Polymorphisms in the General Lebanese Population: The First Report

机译：细胞因子基因多态性的分布一般黎巴嫩人口:第一个报告

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Cytokines are polypeptide regulatory molecules that play a significant role in inflammatory and reg-ulatory responses of the immune system. Several cytokine gene polymorphisms have been studied to date and have been found to be associated with distorted cytokine production or activity by affecting transcriptional regulation and with vulnerability to a variety of infectious and autoimmune diseases as well as to transplant rejection. Results: We studied 106 healthy Lebanese individuals using polymerase chain reaction/sequence-specific priming technique to detect 22 single-nucleotide polymorphisms within 13 cytokine genes: IL1a 889-T/C, IL1I3 511-T/C, IL1B +3962-T/C, IL1R pstl 1970-T/C, IL1RA mspal 11100-T/C, IL4Ra 1902-G/A, IL12 1188-C/A, IFNy 874-A/T, TGFB codon 10-C/T, TGF-B codon 25-G/C, TNFx 308-A/G, TNFc' 238-A/G, IL2 166-G/T, IL2 330-T/G, IL4 1098-T/G, IL4 590-T/C, IL4 33-T/C, IL6 174-C/G, IL6 nt565-G/A, IL10 1082-G/A, IL10 819-C/T, and IL10 592-A/C. We compared our results to those reported in other populations with similarities observed between the Lebanese and the Italian populations. Conclusion: The study of different cytokine poly-morphisms will aid in understanding the susceptibility of populations to various diseases, and this is the first report from the Lebanese community.
机译：细胞因子是多肽分子的监管炎症和发挥重要作用reg-ulatory免疫系统的反应。一些细胞因子基因多态性到目前为止,已经发现学习与生产或扭曲的细胞因子活动影响转录调控与易受各种各样的传染病和自身免疫性疾病以及移植被拒绝。使用聚合酶链黎巴嫩人反应/ sequence-specific启动技术检测22单核苷酸多态性13细胞因子基因:IL1a 889 - t / C, IL1I3 511 - t / C,IL1B 3962-T / C +、IL1R pstl 1970-T / C、IL1RA mspal11100 - t / C, IL4Ra 1902 - g / A, IL12 1188 - C / A, IFNy874 - a / T, TGFB密码子10 C / T, TGF-B密码子25克/ C,TNFx 308 - a / G, TNFc IL2 166 - 238 a / G, G / T, IL2330 - t / G, IL4 1098 - t / G, IL4 590 - t / C, IL4 33辆t / C,白细胞介素6 174 - c / G,白细胞介素6 nt565-G / A, IL10 1082 - G / A, IL10819 - C / T, IL10 592 - a / C。结果发表在其他人群之间的相似之处观察到黎巴嫩和意大利的人口。研究不同的细胞因子poly-morphisms意志帮助理解的易感性人口的各种疾病,这是第一份报告从黎巴嫩社区。

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