• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genetic testing and molecular biomarkers >Frequency of Five Important CYP2D6 Alleles Within an Iranian Population (Eastern Azerbaijan)
【24h】

Frequency of Five Important CYP2D6 Alleles Within an Iranian Population (Eastern Azerbaijan)

机译：五个重要的CYP2D6等位基因的频率伊朗人口东部(阿塞拜疆)

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Polymorphisms in cytochrome P450 genes encoding enzymes of critical importance for drug metabolism have the highest genetic influence on interindividual variations in drug bioavailability. Human CYP2D6 enzyme is claimed to be polymorphically expressed among different ethnic groups. It has been suggested to account for a large part of the interindividual differences in drug metabolism and pharmacokinetics. In the current investigation, 100 healthy unrelated subjects living in Tabriz, Iran, were randomly selected. Genotyping was designed to determine the frequencies of five major and important alleles: CYP2D6*2, CYP2D6*4, CYP2D6*5, CYP2D6*10, and CYP2D6*17. After collecting venous blood samples, polymerase chain reaction—restriction fragment length polymorphism methodology was performed for detection of the alleles (except CYP2D6*5, which has been detected using an allele-specific polymerase chain reaction procedure). Finally, the obtained data were used to determine the allele frequencies. The frequencies for CYP2D6 alleles *2, *4, *5, and *10 were 32%, 12.5%, 3%, and 9%, respectively. CYP2D617 was completely absent in this study group. Poor metabolizer phenotype can be related to *4/*4 and *4 /*5 genotypes with a total frequency of 4%. This is the first study of the CYP2D6 genetic polymorphism in an Iranian population. The frequencies of the studied alleles resulted in degrees of differences between this population and Orientals, Saudi Arabians, and Caucasians, while similarities to the reported results obtained from the studies among Mediterraneans and South Indians are noticeable.
机译：多态性在细胞色素P450基因编码酶药物至关重要新陈代谢有最高的遗传影响个人间的差异药物生物利用度。以多态方式表达不同民族。个人间的很大一部分在药物代谢和差异药物动力学。100名健康无关的主题生活在大不里士,伊朗,是随机选择的。旨在确定频率的5主要和重要的等位基因:CYP2D6 * 2、CYP2D6 * 4,CYP2D6 CYP2D6 * 5 * 10, CYP2D6 * 17。收集静脉血样,聚合酶链式reaction-restriction片段长度多态性的方法进行检测等位基因(除了CYP2D6 * 5,已被发现使用一个allele-specific聚合酶链式反应过程)。被用来确定等位基因频率。CYP2D6等位基因的频率* 2 * 4 * 5和* 10 32%,12.5%,3%,和9%,分别。这个研究小组。有关4 * 4 / *和* / * 5的基因型总频率为4%。伊朗的CYP2D6基因多态性人口。等位基因导致的差异这个人口和东方人之间,沙特阿拉伯人,白种人,而相似之处从研究报告的结果在地中海型和南印度人明显。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号