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首页> 外文期刊>Genetic testing and molecular biomarkers >The Analysis of the Relationship Between Al298C and C677T Polymorphisms of the MTHFR Gene with Prostate Cancer in Eskisehir Popul
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The Analysis of the Relationship Between Al298C and C677T Polymorphisms of the MTHFR Gene with Prostate Cancer in Eskisehir Popul

机译：分析Al298C之间的关系与MTHFR基因C677T多态性前列腺癌在埃斯基谢希尔Popul

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摘要

Prostate cancer is the most common cause of cancer deaths in men and is a major health problem worldwide. Methylene tetrahydrofolate reductase (MTHFR) plays an important role for folate metabolism and is also an important source for DNA methylation and DNA synthesis (nucleotide synthesis). The objective of this study was to investigate the relationship between the Al298C and C677T polymorphisms of the MTHFR gene and prostate cancer in the Turkish population. In our study, 93 prostate cancer patients between the ages of 50-89 and a control group of 166 benign prostate hyperplasia patients were evaluated. C677T and Al298C polymorphism ratios were compared among these two groups, and an analysis was made to see if there is a statistically meaningful difference. In this study, it has been observed that C677T polymorphism of the MTHFR gene produces no statistically significant difference for T allele frequency and the genotype frequency in prostate cancer patients and male controls with benign prostate hyperplasia not having prostate cancer, whereas it has been observed that Al298C polymorphism produces a statistically significant difference for C allele frequency in prostate cancer patients and controls and that it also produces a statistically marginal significance for genotype frequencies.
机译：前列腺癌是最常见的癌症的原因之一男人和死亡人数是一个主要的健康问题在全球范围内。叶酸(MTHFR)中扮演一个重要角色新陈代谢,也是一个重要来源DNA甲基化和DNA合成(核苷酸合成)。调查Al298C之间的关系和MTHFR基因C677T多态性前列腺癌在土耳其人口。研究中,93名前列腺癌患者之间年龄在50 - 89和166名对照组良性的前列腺增生患者进行评估。C677T和Al298C多态性比率其中两组相比,和一个分析是是否有统计有意义的差异。观察到的MTHFR C677T多态性基因产生没有统计学意义T等位基因频率和不同基因型频率在前列腺癌患者与良性前列腺癌和男性控制增生没有前列腺癌,而已经观察到Al298C多态性产生一个统计上的显著差异对于C等位基因频率在前列腺癌病人和控制和它也生产统计边际意义的基因型频率。

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