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首页> 外文期刊>Genetic testing and molecular biomarkers >Possible Association of Combined Vitamin D Receptor and Estrogen Receptor Genotypes and Low Bone Mineral Density in Jordanian Postmenopausal Women
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Possible Association of Combined Vitamin D Receptor and Estrogen Receptor Genotypes and Low Bone Mineral Density in Jordanian Postmenopausal Women

机译：可能协会联合维生素D受体,雌激素受体基因型和低在约旦绝经后骨矿物质密度女性

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摘要

The genetics of osteoporosis has been extensively studied over the last 20 years. Many of the studies have been aimed at identifying possible risk factors and possible association with low bone mineral density (BMD). Vitamin D receptor (VDR) and estrogen receptor (ER) gene polymorphisms were the first to be studied. Some studies have shown a possible association for individual VDR and ER or combined VDR and ER genotypes in some populations, and others showed lack of such an association. This study is aiming at identification of a possible association with low BMD in Jordanian postmenopausal women. We used restriction fragment length polymorphisms (RFLPs) to study four polymorphisms in the VDR gene and two polymorphisms in the ER gene. Our sample was composed of 100 normal controls and 120 samples from patients with symptomatic vertebral fractures. The results showed a possible association of the ppxx genotype with low BMD in controls and patients and an association of the AaBbTT genotype with high BMD in control subjects. The AABBTT, AABBTTFF, and AABBTTFFPPXX genotypes showed a possible association with low BMD in patients. Further studies are needed to confirm the last finding since it could be an important predictor of low BMD in the Jordanian population.
机译：骨质疏松症的基因已被广泛研究在过去的20年。研究旨在识别可能的较低的风险因素和可能的协会骨矿物质密度(BMD)。(VDR)和雌激素受体(ER)基因多态性是第一个研究。研究表明,一个可能的协会个人VDR和ER或结合VDR和ER基因型在某些人群,和其他人缺乏这样一个协会。在确定一个可能的联系低BMD在约旦的绝经后妇女。使用限制片段长度多态性(rflp)研究四个VDR多态性基因和两个ER基因多态性。样本由100名正常对照120年样本有症状的患者椎体骨折。可能的协会ppxx基因型和一个低BMD控制和病人协会与高BMD AaBbTT基因型的在对照组。AABBTTFFPPXX基因型显示成为可能与低BMD患者。研究需要确认最后发现因为它可以低的一个重要因素BMD在约旦人口。

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