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首页> 外文期刊>Genetic testing and molecular biomarkers >New Trends in Molecular Biomarker Discovery for Breast Cancer
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New Trends in Molecular Biomarker Discovery for Breast Cancer

机译：分子生物标志物的发现的新趋势乳腺癌

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Breast cancer is one of the most common and leading causes of cancer death in women. Early diagnosis, selection of appropriate therapeutic strategies, and efficient follow-up play an important role in reducing mortality. Recently, HER-2/neu in breast cancer has been routinely used to guide treatment of using Trastuzumab in less than 25-30% of patients. More new biomarkers will be still expected in the future to tailor treatments. However, there are still many obstacles in developing clinically useful biomarker tests for clinical practice. A lack of specificity of tumor markers and lack of sensitivity of testing systems have been noticed, which limit their clinical use. Finding biomarkers for breast cancer could allow physicians to identify individuals who are susceptible to certain types and stages of cancer to tailor preventive and therapeutic modalities based on the genotype and phenotype information. These biomarkers should be cancer specific, and sensitively detectable in a wide range of specimen(s) containing cancer-derived materials, including body fluids (plasma, serum, urine, saliva, etc.), tissues, and cell lines. This review highlights the new trends and approaches in breast cancer biomarker discovery, which could be potentially used for early diagnosis, development of new therapeutic approaches, and follow-up of patients.
机译：乳腺癌是最常见的一种女性癌症死亡的主要原因。诊断,选择适当的治疗策略和有效的后续发挥重要的作用在降低死亡率。her - 2在乳腺癌/ neu经常用于指导使用曲妥珠单抗的治疗小于25 - 30%的病人。将仍然预期在未来裁缝吗治疗方法。临床上有用的开发中的障碍生物标志物检测对临床实践。特异性肿瘤标记和缺乏灵敏度的测试系统已经注意到,限制其临床应用。乳腺癌生物标记物可以允许医生来识别人容易受到某些类型和阶段的癌症制定预防和治疗方法基于基因型和表型信息。这些癌症生物标记应该是具体的,在广泛的敏感检测标本(s)包含cancer-derived材料,包括体液(血浆、血清、尿液、唾液等)、组织和细胞系。审查突出了新趋势和方法在乳腺癌生物标志物的发现,这可能可能用于早期诊断,开发新的治疗方法后续的病人。

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