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首页> 外文期刊>Genetic testing and molecular biomarkers >Methylenetetrahydrofolate Reductase and Angiotensin-Converting Enzyme Gene Polymorphisms Among Saudi Population from Qassim Region
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Methylenetetrahydrofolate Reductase and Angiotensin-Converting Enzyme Gene Polymorphisms Among Saudi Population from Qassim Region

机译：Methylenetetrahydrofolate还原酶和血管紧张素转换酶基因多态性在沙特人口从卡西姆地区

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Background: Hypertension and cardiac diseases are multifactorial disorders with genetic background determined by multiple gene polymorphisms. Methods: This work included 273 healthy unrelated subjects ethnically belonging to the Qassim region. Their age ranged from 18 to 60 years, with a median age of 20 years. They included 152 (55.7%) men and 121 (44.3%) women. Their DNAs were analyzed for genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR; 677C/T and 1298 A/C) as well as angiotensin-converting enzyme genes (ACE; insertion/deletion [I/DD using real-time polymerase chain reaction. Results: Carriers of the mutant MTHFR 677 T allele (CT + TT) and that of the 1298 C allele (CC + AC) constituted 33.7% and 48.9% of studied subjects, respectively, whereas carriers of ACE gene mutant D allele (DD + ID) represented 93.3% of subjects. The allele frequencies of MTHFR 677T, 1298C, and ACE D alleles were 18.7%, 29.45%, and 72.5%, respectively. Haplotype analysis of characterized chromosomes revealed that 2.5% were likely to carry the three mutant alleles together, 30.91% were likely to carry two of the three mutant alleles, and 51.92% were likely to carry one mutant allele. Conclusion: The Saudi population from the Qassim region is a carrier of a relatively large number of genetic alleles predisposing them to hypertension and cardiac diseases. This gives a warning to local health authorities for adoption of competent programs for prevention as well as early diagnosis and management.
机译：背景:高血压和心脏疾病多因子的紊乱和遗传背景由多个基因多态性。方法:这项工作包括273名健康无关主体民族属于卡西姆地区。平均年龄为20年。(55.7%)的男性和121名女性(44.3%)。的遗传多态性进行了分析methylenetetrahydrofolate还原酶(MTHFR;677 C / T和1298 A / C)以及血管紧张素转换酶基因(王牌;使用实时插入/缺失(I / DD聚合酶链反应。677 T等位基因突变MTHFR (CT + TT)的1298 C等位基因(CC + AC)占33.7%分别和48.9%的研究对象,而运营商ACE基因的突变体D等位基因(DD+ ID)代表93.3%的受试者。频率的MTHFR 677 t, 1298 c, a D等位基因分别为18.7%、29.45%和72.5%,分别。染色体显示,2.5%可能携带三突变等位基因,30.91%有可能携带的两个三个突变有可能把一个等位基因,和51.92%突变的等位基因。从卡西姆地区是一个载体相对大量的基因等位基因诱发高血压和心脏疾病。当局采用主管项目为预防和早期诊断管理。

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