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首页> 外文期刊>Genetic testing and molecular biomarkers >Combined Hepatic Lipase -514C/T and Cholesteryl Ester Transfer Protein 1405V Polymorphisms Are Associated with the Risk of Coronary Artery Disease
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Combined Hepatic Lipase -514C/T and Cholesteryl Ester Transfer Protein 1405V Polymorphisms Are Associated with the Risk of Coronary Artery Disease

机译：结合肝脂肪酶-514 c / T和胆甾醇酯转运蛋白1405 v多态性与冠状动脉的风险有关疾病

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摘要

Hepatic lipase (LIPC) and cholesteryl ester transfer protein (CETP) are important components of high-density lipoprotein (HDL) metabolism and reverse cholesterol transport. Therefore, their genes are promising candidate genes for cardiovascular disease. The aim of the present study was to investigate whether combined LIPC - 514C /T and CETP 1405V polymorphisms correlate with angiographically documented coronary artery disease ( CAD). Genotyping was performed in 317 patients who underwent clinically indicated coronary angiography. The patients were classified with significantly diseased arteries if one or more coronary arteries had a stenosis >50% and with minimally diseased arteries if there was no significant stenosis (<40%) in any artery. There were no significant associations of individual polymorphisms with the risk of significant CAD. In a multivariate logistic regression analysis including cardiovascular risk factors, simultaneous presence of both LIPC -514T and CETP 405V alleles was an independent predictor of significantly diseased arteries (odds ratio = 2.04; p= 0.022). This association was not significant in women with combined genotype who had the highest HDL-cholesterol. In conclusion, the combined T allele of LIPC -514C/T and V allele of CETP 1405V are associated with the risk of CAD. Further, the higher HDL-cholesterol and female gender may reduce the effect of combined genotype on CAD risk.
机译：肝脂肪酶(LIPC)和胆甾醇酯转运蛋白(CETP)是重要的组件高密度脂蛋白(HDL)和新陈代谢反向胆固醇运输。基因是有希望的候选基因心血管病研究旨在探讨是否LIPC——相结合胆固醇酯转运蛋白1405 v 514 c / T多态性相关冠状动脉血管摄影记录疾病(CAD)。病人临床表示冠状动脉造影。分类与动脉明显病变如果一个或更多的冠状动脉狭窄> 50%,与最低限度的动脉没有任何的显著狭窄(< 40%)动脉。个体多态性的风险重要的CAD。回归分析包括心血管疾病的风险LIPC -514 t的因素,同时存在胆固醇酯转运蛋白405 v和等位基因是一个独立的预测显著病变的动脉(优势比= 2.04;并没有显著的女性结合脂蛋白胆固醇最高的基因型。结论,结合T等位基因的LIPC -514 c / T胆固醇酯转运蛋白1405 V和V的等位基因相关联计算机辅助设计的风险。脂蛋白胆固醇和女性的性别可能会减少结合基因型对CAD的影响的风险。

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