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Autologous transplantation of CD133 selected hematopoietic progenitor cells in a pediatric patient with relapsed leukemia.

机译:CD133选定造血祖细胞的自体移植在复发性白血病的小儿患者中。

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摘要

A pediatric patient with very early meningeal relapse of his CD34(+) CD133(-) pre-B-ALL was transplanted with 2.5 x 10(6)/kg CD133 selected autologous progenitor cells. Enrichment of CD133(+) cells resulted in a purity of 92.3 +/- 3.5% CD133(+). Hematopoietic engraftment with >1.0 x 10(9)/l neutrophils and >50 x 10(9)/l platelets was reached within 13 and 24 days, respectively. At a follow-up of 11(1/2) months after autologous transplantation, the patient is in complete remission. To our knowledge, the successful transplantation with a CD133 selected graft is the first one to be reported worldwide. CD133 selected cells may serve as an alternative in the case of CD34(+) malignancy.
机译:一名小儿脑膜复发非常早的CD34(+)CD133(-)pre-B-ALL儿童患者被移植了2.5 x 10(6)/ kg CD133选定的自体祖细胞。 CD133(+)细胞的富集导致纯度为92.3 +/- 3.5%CD133(+)。分别在13和24天内达到造血细胞植入> 1.0 x 10(9)/ l血小板和> 50 x 10(9)/ l血小板。自体移植后的11(1/2)个月的随访中,患者已完全缓解。据我们所知,用CD133选定的移植物成功移植是全世界第一个报道的移植物。在CD34(+)恶性肿瘤的情况下,选择的CD133细胞可以作为替代。

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