...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archiv der Pharmazie >Potent inhibitory effects of resveratrol derivatives on progression of prostate cancer cells.
【24h】

Potent inhibitory effects of resveratrol derivatives on progression of prostate cancer cells.

机译：白藜芦醇衍生物对前列腺癌细胞发展的有效抑制作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Resveratrol has been identified as a potent anticancer agent in a variety of studies. In this study, several resveratrol derivatives were synthesized and investigated in the search for an anticancer agent with higher efficacy than resveratrol. During our examination of cancer cell lines, compounds C, F, and G evidenced higher inhibitory activity than resveratrol with regard to the growth of PC-3 and LNCaP human prostate cancer cells. Moreover, four derivatives of resveratrol evidenced potent growth inhibitory activity (IC50 0.01-0.04 microM) in LNCaP cells. The levels of activity in these derivatives were 25-100 times stronger than that associated with resveratrol (IC50 1.0 microM). Our results suggested that compounds C, D, F, and G might function as anticancer agents on prostate tumors. This study also contains a discussion regarding the structure-activity relationships of several resveratrol derivatives.
机译：白藜芦醇在各种研究中已被确认为有效的抗癌药。在这项研究中，合成了几种白藜芦醇衍生物，并进行了研究，以寻找比白藜芦醇具有更高功效的抗癌药。在我们对癌细胞系的检查中，化合物C，F和G在PC-3和LNCaP人前列腺癌细胞的生长方面显示出比白藜芦醇更高的抑制活性。此外，白藜芦醇的四种衍生物在LNCaP细胞中显示出有效的生长抑制活性（IC50 0.01-0.04 microM）。这些衍生物的活性水平比白藜芦醇（IC50 1.0 microM）高25-100倍。我们的结果表明，化合物C，D，F和G可能对前列腺肿瘤起抗癌作用。这项研究还包含有关几种白藜芦醇衍生物的构效关系的讨论。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号