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首页> 外文期刊>Archiv der Pharmazie >Synthesis, characterization and antimycobacterial activity of ag(i)-aspartame, ag(i)-saccharin and ag(i)-cyclamate complexes.
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Synthesis, characterization and antimycobacterial activity of ag(i)-aspartame, ag(i)-saccharin and ag(i)-cyclamate complexes.

机译：Ag（i）-阿斯巴甜，ag（i）-糖精和Ag（i）-甜蜜素复合物的合成，表征和抗分枝杆菌活性。

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摘要

The present work describes the synthesis and antimycobacterial activity of three Ag(I)-complexes with the sweeteners aspartame, saccharin, and cyclamate as ligands, with the aim of finding new candidate substances for fighting tuberculosis and other mycobacterial infections. The minimal inhibitory concentration of these three complexes was investigated in order to determine their in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium malmoense, and Mycobacterium kansasii. The MIC values were determined using the Microplate Alamar Blue Assay. The best MIC values found for the complexes were 9.75 muM for Ag(I)-aspartame against M. kansasii and 15.7 muM for Ag(I)-cyclamate against M. tuberculosis.
机译：本工作描述了三种甜味剂阿斯巴甜，糖精和甜蜜素为配体的Ag（I）配合物的合成和抗分枝杆菌活性，目的是寻找对抗结核和其他分枝杆菌感染的新候选物质。为了确定它们对结核分枝杆菌，鸟分枝杆菌，胞内分枝杆菌，马尔默分枝杆菌和堪萨斯分枝杆菌的体外抗分枝杆菌活性，研究了这三种复合物的最小抑菌浓度。使用Microplate Alamar Blue测定法测定MIC值。对于该复合物发现的最佳MIC值是针对堪萨斯分枝杆菌的Ag（I）-阿斯巴甜的9.75μM和针对结核分枝杆菌的Ag（I）-甜蜜素的15.7μM。

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