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首页> 外文期刊>Applied in vitro toxicology. >Protective Effects of Luteolin and Gallic Acid Against Storage-Induced Oxidative Damage in Whole Blood of Female Wistar Rats
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Protective Effects of Luteolin and Gallic Acid Against Storage-Induced Oxidative Damage in Whole Blood of Female Wistar Rats

机译：毛地黄黄酮的保护作用和没食子酸针对Storage-Induced氧化损伤女性Wistar鼠的血

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Introduction: Whole blood undergoes oxidative stress that precipitates biochemical changes that can lead to lesions during storage. This study attempts to evaluate the effectiveness of gallic acid and luteolin separately and in their combined state against oxidative damage during blood storage.Materials and Methods: Rats were grouped into control and experimental. Blood collected was stored for 28 days at 4°C. On day 0, 14, and 28, blood was withdrawn to study oxidative stress markers, antioxidant enzymes, and protein oxidation products.Results: Catalase activity reduced in all groups. Thiobarbituric acid reactive substance (TBARS) level increased in control without antioxidants (p < 0.05). Combined antioxidants or when separately added at lower concentrations, significantly reduced the TBARS level. Individual antioxidants at higher concentrations increased TBARS as compared with control (p < 0.05; p < 0.01). Decrease in superoxide dismutase activity observed in control was prevented by the antioxidants. Protein sulfhydryl level was restored and sustained until the last day of storage in groups that received individual antioxidants at both concentrations and the combined form at a lower concentration. Addition of either luteolin or gallic acid and their combined form reduced advanced oxidation protein products formation noticed in the control during storage.Conclusions: Luteolin and gallic acid were beneficial in the area of increased antioxidant capacity, prevention of protein product formation, and maintenance of sulfhydryl level. Their combination also showed a synergistic effect that offered a potential to improve long-term storage of whole blood. The antioxidants could possibly collaborate to be excellent potential blood storage additives providing protection against oxidative damage through their antiradical properties.
机译：作品简介:全血进行氧化强调沉淀生化变化储存期间会导致病变。试图评估高卢的有效性酸和木樨草素分别和他们结合国家对氧化损伤血液存储。分为控制和实验。收集的是存储在4°C为28天。0、14和28岁的血液被撤回氧化应激标记、抗氧化酶、和蛋白质氧化产品。在所有团体活动减少。酸活性物质(TBARS)水平增加在控制抗氧化剂(p < 0.05)。结合抗氧化剂或当单独添加低浓度,显著减少了TBARS水平。浓度增加TBARS相比控制(p < 0.05;超氧化物歧化酶活性观察控制阻止了抗氧化剂。恢复和持续直到巯基水平存储组的最后一天个人抗氧化剂的浓度低浓度和组合形式。毛地黄黄酮或没食子酸和他们的结合形成了先进的氧化蛋白质产品形成发现在控制在存储。酸是有益的在增加蛋白质的抗氧化能力、预防产品的形成和巯基的维护的水平。提供了一个潜在的协同效应提高全血的长期储存。抗氧化剂可能合作优秀的潜在的血液储存添加剂提供保护免受氧化损伤通过他们的反激进主义的性质。

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